- Disable VSync, this did not work for me but may work for you

2 - Plug into a USB 2.0 port (my fix) I noticed it was happening in Windows as well, I have not encountered the issue since then. Its funny cause I was using USB 3.0 and then noticed my motherboard has USB ports labeled "gaming USB ports" - Using these fixed the problem, I believe they are just USB 2.0 ports but I have not had an issue since I plugged into these.

also do this: Check your windows event LOG (anything with errors in there under "System" should be addressed if they are time stamped while you are playing. Use the googles to find out how to fix them.

Right so it might be also that your windows is trying to install several HID compliant devices under the same GUID too, which menas your computer is disabling/enabling mouse by changing through the HID

Worst case try XHCI Mode = Disabled - The on-board USB 3.0 port function like a 2.0 port
in bios