intel_idle.max_cstate=0 idle=poll quiet cgroup_enable=memory crashkernel=256M intel_pstate=disable

[mysql]
default-character-set=utf8mb4
user = root
password = 123456
port = 3306
socket = /tmp/mysqld.sock
prompt="\u@\h \d>"

[mysqld]
# basic settings #
user = mysql
bind-address = 0.0.0.0
socket = /tmp/mysqld.sock
character_set_server = utf8mb4
transaction_isolation = READ-COMMITTED
explicit_defaults_for_timestamp = 1
max_allowed_packet = 16777216
event_scheduler = 1
default_password_lifetime = 0
autocommit = 1
server-id = 1
sql_mode = "STRICT_TRANS_TABLES,NO_ENGINE_SUBSTITUTION,NO_ZERO_DATE,NO_ZERO_IN_DATE,ERROR_FOR_DIVISION_BY_ZERO,NO_AUTO_CREATE_USER"

# connection #
interactive_timeout = 1800
wait_timeout = 1800
lock_wait_timeout = 1800
skip_name_resolve = 1
max_connections = 512
max_connect_errors = 1000000

# table cache performance settings #
table_open_cache = 4096
table_definition_cache = 4096
table_open_cache_instances = 128  #最大64

# session memory settings #
read_buffer_size = 16M
read_rnd_buffer_size = 32M
sort_buffer_size = 32M
tmp_table_size = 64M
join_buffer_size = 128M
thread_cache_size = 64

# log settings #
log_error = error.log
log-bin = mysql-bin
slow_query_log = 1
slow_query_log_file = slow.log
log_queries_not_using_indexes = 1
log_slow_admin_statements = 1
log_slow_slave_statements = 1
log_throttle_queries_not_using_indexes = 10
expire_logs_days = 30
long_query_time = 2
min_examined_row_limit = 100
binlog-rows-query-log-events = 1
log-bin-trust-function-creators = 1
log-slave-updates = 1

# innodb settings #
innodb_page_size = 16384
innodb_buffer_pool_size = 160G
innodb_buffer_pool_instances = 16
innodb_buffer_pool_load_at_startup = 1
innodb_buffer_pool_dump_at_shutdown = 1
innodb_lru_scan_depth = 4096
innodb_lock_wait_timeout = 5
innodb_io_capacity = 10000
innodb_io_capacity_max = 20000
innodb_flush_method = O_DIRECT
innodb_file_format = Barracuda
innodb_file_format_max = Barracuda
innodb_undo_logs = 128
innodb_undo_tablespaces = 3
innodb_flush_neighbors = 0
innodb_log_file_size = 17179869184
innodb_log_files_in_group = 2
innodb_log_buffer_size = 16777216
innodb_purge_threads = 4
innodb_large_prefix = 1
innodb_thread_concurrency = 64
innodb_print_all_deadlocks = 1
innodb_strict_mode = 1
innodb_sort_buffer_size = 67108864
innodb_write_io_threads = 16
innodb_read_io_threads = 16
innodb_file_per_table = 1
innodb_stats_persistent_sample_pages = 64
innodb_autoinc_lock_mode = 2
innodb_online_alter_log_max_size=1G
innodb_open_files=4096
innodb_flush_log_at_trx_commit=1

# replication settings #
master_info_repository = TABLE
relay_log_info_repository = TABLE
sync_binlog = 1
gtid_mode = on
enforce_gtid_consistency = 1
log_slave_updates
binlog_format = ROW
binlog_rows_query_log_events = 1
relay_log = relay.log
relay_log_purge = 1
relay_log_recovery = 1
report-port = 3306
report-host = 10.106.144.11
slave_skip_errors = ddl_exist_errors
slave-rows-search-algorithms = 'INDEX_SCAN,HASH_SCAN'

# semi sync replication settings #
plugin_load = "validate_password.so;rpl_semi_sync_master=semisync_master.so;rpl_semi_sync_slave=semisync_slave.so"
rpl_semi_sync_master_enabled = 1
rpl_semi_sync_master_timeout = 3000
rpl_semi_sync_slave_enabled = 1

# password plugin #
validate_password_policy=STRONG
validate-password=FORCE_PLUS_PERMANENT

[mysqld-5.6]
# metalock performance settings
metadata_locks_hash_instances=64

[mysqld-5.7]
# new innodb settings #
loose_innodb_numa_interleave=1
innodb_buffer_pool_dump_pct = 40
innodb_page_cleaners = 16
innodb_undo_log_truncate = 1
innodb_max_undo_log_size = 2G
innodb_purge_rseg_truncate_frequency = 128

# new replication settings #
slave-parallel-type = LOGICAL_CLOCK
slave-parallel-workers = 16
slave_preserve_commit_order=1
slave_transaction_retries=128

# other change settings #
binlog_gtid_simple_recovery=1
log_timestamps=system
show_compatibility_56=on
I assume the MySQL Server as followings. You should tune the variables according to your server.

32 CPU core
256G Memory
SSD storage with 20000 IOPS in 16K page size