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/femgen/ HRT Nov. 6th 2016

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Nov 6th, 2016
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  1. WARNING: This is illegal in the US and Europe unless the medical system is involved. It may also be cost-prohibitive. This article recommends purchasing chemicals at alldaychemist.com (ADC) an Indian grey-market pharmacy. You can also use inhousepharmacy.vu (IHP), qhi.co.uk (QHI), kiwidrug.com, and of course darknetmarkets and alibaba. Regardless of where you buy, expect at least 2 weeks shipping. If you live in a country where mail is searched, look to local suppliers, darknetmarkets, and ADC in that order. Transporting illegal pharmaceuticals across state lines in the United States is a felony.
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  3. N.B.: This guide does not recommend under any circumstance the excessive consumption of phytoestrogens or supplements. They do nothing. Altering your diet will change very little. Altering your biochemistry will change very much.
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  5. This pertains to post or mid-pubescent biological males. If you are past the age of 24 you will find it very difficult if not impossible to become androgynous. Most males reach sufficient sexual dimorphism to avoid androgyny by the age of 16. The majority of truly androgynous icons (Andreja, Stav, etc) have been blocking testosterone from an early age. The sooner one starts, the greater the chance of androgyny. Generally speaking, everything in the body other than bones will be restructured over time with changing hormones. Ask yourself: is my bone structure itself visibly masculine? This doesn't include muscles, fat distribution, skin, and body hair. If the answer is yes, you will probably never look androgynous. To be physically androgynous, one can take either Estrogen (E), Selective Estrogen Receptor Modulators (SERMs), or an Androgen Blockade (ADT).
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  7. Each involve an anti-androgen (AA). Androgen refers to testosterone, the primary male sex hormone. There are dozens of AAs. Most will make you permanently sterile after extended usage (2+ years). We focus on three:
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  9. Spironolactone (FDA-Branded Aldactone), the most common AA used in the US. Cheap, safe, weak. Average daily dose: 200mg. Typical range: 100-300mg. Bulk cost on ADC: $10/month
  10. Cyproterone Acetate (FDA-Branded Androcur), the most common AA in Europe. Invasive, strong. Average daily dose: 50mg. Typical range: 25-100mg. Bulk cost on ADC: $45/month
  11. Bicalutamide (FDA-Branded Calutide), an obscure AA which does not result in permanent infertility. Expensive, experimental, strong. Average daily dose: 50mg. Typical range: 25-75mg. Bulk cost on ADC: $50/month. Cheaper at kiwidrug.
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  13. We are very interested in bicalutamide's ability to prevent sterility and masculinizing. It works only by blocking androgens from binding to the androgen receptor, not by stopping androgen production. It also induces nuclear translocation after binding [1]. Therefore, the effect of DHT (Dihydrotestosterone--a more potent testosterone) will be decreased despite its production being increased and DHT having a stronger binding affinity for the androgen receptor than bicalutamide. It has has loss of libido in few cases, indicating reduced, but not eliminated, blood-brain barrier penetration [2]. Due to the non-androgenic anabolic effects of testosterone, it does not induce muscle loss [3].
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  16. On E, SERMs, ADT
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  18. Estrogen: Note that you will grow breasts (ymmv) and likely become sterile (in 3 months to 2 years) even with bicalutamide.
  19. On average, take 4mg of Estradiol (hemihydrate > valerate) (FDA-Branded Estrofem, Progynova) along with your AA. For results, see: http://i.imgur.com/UhB4Ybz.png
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  22. SERMs: Note that few people take these, but no complications have been locally reported. A SERM works in conjunction with an AA to mitigate the side effects of singularly taking AAs (osteoporosis, breast growth, depression, etc.) by triggering certain estrogen receptors and blocking others. SERMs are often given to post-menopausal women to reduce the risk of breast cancer; they represent the majority of research subjects. Bodybuilders occasionally illegally purchase SERMs (and sometimes SARMs) to use in conjunction with certain steroids. The SERMs outlined below are all breast tissue antagonists; they prevent breast growth and reduce breast size over time (experimental half life of around 2-3 months).
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  24. The chemicals in order of desirability: Raloxifene (R) (FDA-Branded Evista) > Tamoxifen (T) >> Clomifene (C)
  25. Average daily doses: R: 60mg, T: 20mg, C: 50mg. Ranges: unknown
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  27. Tamoxifen can induce cognitive dysfunction [4].
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  29. Raloxifene can fix cognitive dysfunction caused by antipyschotics in the treatment of schizophrenia [5]. It can also act as an antidepressant [6][7]. It has some effects on the serotonin system, and can improve memory and attention in healthy patients [8].
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  32. Androgen Blockade: Also known as Androgen Deprivation Therapy, commonly used to treat prostate cancer. This should only be done under the specific direction of an endocrinologist. It can induce such side effects as a bad lipid profile, osteoporosis, and hot flashes without a SERM or full estrogen being used [9].
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  34. @ discord.gg/faBYaap
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  36. [1] http://www.jbc.org/content/277/29/26321.full
  37. [2] http://www.antialabs.com/reference/21018026.pdf
  38. [3] https://www.ncbi.nlm.nih.gov/pubmed/20950306
  39. [4] https://link.springer.com/article/10.1023%2FA%3A1006426132338
  40. [5] https://www.ncbi.nlm.nih.gov/pubmed/27193386
  41. [6] https://www.ncbi.nlm.nih.gov/pubmed/20961269
  42. [7] https://www.ncbi.nlm.nih.gov/pubmed/22061801
  43. [8] https://www.ncbi.nlm.nih.gov/pubmed/15577134
  44. [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213888/
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