defaultConfig {
        multiDexEnabled true

depenencies {
   ...
   compile 'com.android.support:multidex:1.0.1'
   ...
}

02-21 16:07:05.043 3348-3348/? E/memtrack: Couldn't load memtrack module (No such file or directory) 02-21 16:07:05.043 3348-3348/? E/android.os.Debug: failed to load memtrack module: -2 02-21 16:07:19.723 3359-3359/? E/memtrack: Couldn't load memtrack module (No such file or directory) 02-21 16:07:19.723 3359-3359/? E/android.os.Debug: failed to load memtrack module: -2 02-21 16:07:19.923 2015-2015/com.google.android.gms E/dalvikvm: Dex cache directory isn't writable: /data/dalvik-cache 02-21 16:07:19.923 2015-2015/com.google.android.gms E/ChimeraModuleLdr: Initialization failed for module apk com.google.android.play.games
                                                                        java.lang.ClassNotFoundException: Didn't find class "com.google.android.gms.chimera.GmsModuleInitializer" on path: DexPathList[[zip file "/system/app/PlayGames.apk"],nativeLibraryDirectories=[/vendor/lib, /system/lib]]
                                                                            at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
                                                                            at java.lang.ClassLoader.loadClass(ClassLoader.java:497)
                                                                            at csg.loadClass(:com.google.android.gms@11947030:3)
                                                                            at java.lang.ClassLoader.loadClass(ClassLoader.java:457)
                                                                            at com.google.android.gms.chimera.container.GmsModuleApi.onApkLoaded(:com.google.android.gms@11947030:1)
                                                                            at csm.a(:com.google.android.gms@11947030:88)
                                                                            at csm.a(:com.google.android.gms@11947030:35)
                                                                            at csm.a(:com.google.android.gms@11947030:118)

public class MyApplication extends MultiDexApplication { ... }

<?xml version="1.0" encoding="utf-8"?>
<manifest xmlns:android="http://schemas.android.com/apk/res/android"
    package="com.example.myapp">
    <application
            android:name="android.support.multidex.MultiDexApplication" >
        ...
    </application>
</manifest>

public class MyApplication extends SomeOtherApplication {
  @Override
  protected void attachBaseContext(Context base) {
     super.attachBaseContext(context);
     Multidex.install(this);
  }
}