from boto.s3.connection import S3Connection


file_to_upload = "e434b232c2e4f70aa2819d708dfd30fb4cebcf6c.zip"

s3 = S3Connection(YOUR_AWS_ACCESS_KEY, YOUR_AWS_SECRET_KEY)
bucket = s3.get_bucket(YOUR_BUCKET_NAME)

# user will receive "mixtape.zip" instead of "e434b232c2e4f70aa2819d708dfd30fb4cebcf6c.zip"
s3_headers = {'Content-Disposition': "attachment; filename=mixtape.zip"}

mt_key = bucket.new_key(file_to_upload)
mt_key.set_contents_from_filename(/path/to/file_to_upload,
                                  headers=s3_headers)