For i = .Rows.Count To 1 Step -1
        If .Item(i) = "w" Or "x" Or "y" Or "z" Then

            .Item(i) = "A"

        End If
    Next i

If .Item(i) = "w" Or .Item(i) = "x" Or .Item(i) = "y" Or .Item(i) = "z" Then

For i = .Rows.Count To 1 Step -1
     Select Case .Item(i)
         Case "w", "x", "y", "z"
             .Item(i) = "A"
         Case "something else"
             'If you have other criteria
         Case Else
             'If you have a action item for something that isn't any of the above
     End Select
 Next i

Dim arr() As String: arr = Split("w,x,y,z", ",")
For i = .Rows.Count To 1 Step -1
    For j = LBound(arr) To UBound(arr)
        If .Item(i) = arr(j) Then .Item(i) = "A"
    Next j
Next i