#OpRodent FDA EMAIL LEAK

From: Gordon, Indya
Sent: Friday, November 19, 1999 10:13 AM
To: Dockets, FDA
Subject: FW: Tordoff: aspartame doesn't increase hunger & weight 6.9.99

94F-0405

-----Original Message-----
From: Henney, Jane
Sent: Friday, June 18, 1999 1:40 AM
To: EXECSEC
Subject: FW: Tordoff: aspartame doesn't increase hunger & weight 6.9.99




> ----------
> From: 	Richard T. Murray[SMTP:RMFORALL@EARTHLINK.NET]
> Sent: 	Friday, June 18, 1999 1:30:43 AM
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> Subject: 	Tordoff: aspartame doesn't increase hunger & weight 6.9.99
> Auto forwarded by a Rule
>
Subject: Re: aspartame
        Date: Wed, 9 Jun 1999 13:29:19 -0400
       From:  "Michael Tordoff" <tordoff@monell.org>
 Organization: http://extra.newsguy.com
 Newsgroups: sci.med.nutrition

Laurel Amberdine <circle@NOSPAMmtco.com> wrote in message
news:jhj73.38$st2.6200@iagnews.iagnet.net...
> SharpGymn <sharpgymn@aol.com> wrote in message
> news:19990608123748.22541.00001360@ngol02.aol.com...
> > Consuming aspartame seems to trigger a hunger type feeling, even if
> > I have just eaten, whereas if I abstain from aspartame, I would be
> > satisfied.  Does this have any scientific validity, or am I just
> > imagining it?  I really get ravenous after consuming "straight"
> > aspartame like in a diet coke, versus aspartame added to a food,
> > like a milkshake or oatmeal sweetened w/ aspartame.
>
>
> Actually, this is the only real problem I know of from aspartame.  (I
> suppose any artificial sweetener might do the same.)  The sweet taste
> causes you to secrete insulin in anticipation of sugar.  Since there
> isn't any real food there, your blood sugar drops and you get hungry.
>
> People with this problem should prolly eat something when they have
> aspartame.  I still think its a better idea than sugary soda.
>
> -Laurel
>
>
>
First, there is good, valid evidence that ingesting aspartame can
increase feelings of hunger.  The original work was done by John
Blundell (Blundell, J.E., and Hill, A.J. Paradoxical effects of an
intense sweetener (aspartame) on appetite. Lancet i: 1092-1093, 1986).
and I have published similar findings in which the aspartame was
embedded in chewing gum (Tordoff, M.G., and Alleva, A.M.
Oral stimulation with aspartame increases hunger.
Physiology and Behavior 47: 555-559, 1990).
This work also shows a complex, gender-related sweetness-response
effect, which may explain why you feel "ravenous" after consuming some
aspartame-containing products but not others.  There are several
published reports from other groups as well, but also at least an equal
number of failures to find an effect of aspartame on hunger.

My reading of the literature is that there is a very, very small effect
of aspartame to increase hunger-- so small that it is practically
undetectable in the real world, outside the lab.  Moreover, although
there may be an increase in hunger, it is even less clear whether this
translates into an increase in food intake.  One thing that is clear,
however, is there are no studies showing that consuming aspartame
increases body weight-- if anything the data point in the other
direction.

Second, it is tempting to think this increased hunger produced by
consuming asparatme is due to "anticipatory" changes in insulin levels,
which is termed the "cephalic phase insulin response".  However, the
evidence is against it.  The best paper on this topic is by my
colleague, Karen Teff (Teff, K.L., Devine, J., and Engelman, K.
Sweet taste: effect on cephalic phase insulin release in men.
Physiol Behav 57: 1089-95, 1995).  There are many cephalic phase
responses, such as salivation, gastric acid production, and changes
in liver metabolism, and it's my guess that one of these other
responses is responsible for the appetite.

I hope this helps

Michael Tordoff
Monell Chemical Senses Center
Philadelphia