'Yep, ISRIB works perfectly orally without DMSO. It is the only way I’m consuming this stuff now. I’ve tried in rectally (solution ISRIB + DMSO + Glycerine (a little bit, because dmso rectally goes very painfully), before “infusing” it in my.... I’m using loperamide rectally because glycerine and dmso will hardly trying to go back)). Rectally it works good, better then orally without dmso (I’m a little bit scary about trying it orally with dmso.. dmso is so bad to drink this shit). I also tried in intravenously, solution ISRIB + DMSO (2mg isrib per 1ml dmso) and it was very painful, I was was screaming because of pain. Pure solution of dmso sucks, my veins were fucked up. Now I’m going to buy PEG-400 and then try the next solution intravenously: per 5mg ISRIB — 1ml DMSO + 1mg PEG-400. My friends from Russia have tried 50mg of ISRIB intravenously in 1 day in two passes. Then they had strongly hypomanic state, mad motivation, sleep for 5 hrs and so on. They said that ISRIB solution in PEG-400 + DMSO (1:1) were not painful. And it is good. I’ve also tried ISRIB intranasal. Can’t say exactly was it better than orally.. maybe yes, maybe no. I don’t know. One of my friends said that you can solute ISRIB in PEG-400 and consume it intranasal. Maybe. I’m thinking of synthesizing cyclodextrine complex with ISRIB. Maybe then (I suppose so), this complex will solute in water, so there would not be such problems with ISRIB consumption (it would be my own development). My typical dosage is about 15mg orally without DMSO. After 5 minutes I feel a strong surge of energy. I’m dosing it everyday for a week. Throughout this time, perhaps the most severe depressive episode of my life that had finally ended, I can live without kratom much longer (I am addicted for about year to kratom), almost without discomfort. The need for sleep decreased for about 30% and when I’m waking up, I feel a lot of energy. I never become tired, although I’m working hard in org chemistry lab and we are preparing a very huge science article about isoxazolines, and after work I have enough mental energy for studying. My memory and ability to perceive information significantly improved, my appetite increased twice. I need to eat a lot, because ISRIB allows the body to expend much more energy, correcting an evolutionarily resulting defect in the cellular system of protein synthesis (integrated response to a low stress, there is growing evidence of persistent, smoldering ISR activation in neurodegenerative diseases and conditions exhibiting memory consolidation defects, such as traumatic brain injury; but ISRIB can not antagonize the effects of high P-eIF2a levels (the result of ISR activation), induced by various viral infections, so you’ll not die due to coronavirus. However, ISRIB is not only the PERK (that is activated by different endoplasm. reticulum). It also inhibits GCN2 (that is activated by amino acid deprevation), HRI (activated by heme deprevation or in the presence of heavy metals) and PKR (activated by viral infections). ISRIB inhibits ISR, that means that eIF2 (eukaryotic initiation factor 2, wich participates in initiation of protein synthesis (translation)) becomes insensitive for his kinases which I have listed above. Isrib helps in killing agressive prostate cancer (https://pubmed.ncbi.nlm.nih.gov/29720449/). It helps with social anxiety (https://pubmed.ncbi.nlm.nih.gov/28584287/), normalize the behavioral and neuropsychological abnormalities in Down syndrome (https://pubmed.ncbi.nlm.nih.gov/31727829/), helps with diabetic hepatotoxity by antagonizing PERK-eIF2a-ATF4 pathway (https://pubmed.ncbi.nlm.nih.gov/30877037/), helps with methylglyoxal-induced pain (https://pubmed.ncbi.nlm.nih.gov/30157134/), supresses MEHMO syndrome mutation (https://pubmed.ncbi.nlm.nih.gov/31836389/) and so on, and so on. It may help with alzheimer disease, TBI, maybe parkinson syndrome, and with some types of cancer. One of my friends from Russia (now he is studying in UK) was one of the first guys that had tried this stuff. He had a brain trauma (automobile accident) in a childhood. Then he has hardly fucked up with an idea of repairing his brain. He analyzed his brain on MRT (I’ll show this photos) and a big part of PFC was totally fucked. After a course of ISRIB he scanned his brain one more time and all was good (don’t have the MRT photo, only a doctors conclusion, but it is russian language there). As for me, I can totally say. It's hard to judge my current state compared to pre-ISRIB... New baselines created all the time, so I don't really know where the bottom was compared to the new heights. it seems like anything that is somewhat less than what my current state seems like a horrible existence... I just need to go higher and higher... Does that make sense? I really do not give a single fuck about my body so long as my mind functions at a level that I am satisfied with. Also, I wonder if me snorting some IDRA-21 and ISRIB in combine before doing some drugs (like acid, alcohol, valium, weed, etc). Integrated response to low stress is, essentially, a limiter of our energy potential. Previously, for example, when there was a lack of food, people was turned on to save energy. Now, in the conditions of the modern world, such a function is not needed. Isrib allows you to consume more food and this, for a minute, is an evolutionary breakthrough. All evolutionary leaps have been associated with the ability to use more energy. This drug has enormous therapeutic potential, therefore further research in humans is required.'