Microbiome: the missing link to health and longevity

Microbiome: the missing link to health and longevity

Hippocrates, the ancient Greek physician and “Father of Modern Medicine,” once said that
 all disease starts in the gut.

The human microbiome symbiotically takes signals from the host organism and produces peptides, etc on demand, for more purposes than we can currently quantify.

http://med.stanford.edu/news/all-news/2019/08/human-microbiome-churns-out-thousands-of-tiny-novel-proteins.html

The list of gut microbiome<->host interactions being documented is growing every week, but given the 40000 chemicals in our foods

https://www.nature.com/articles/s43016-019-0005-1

and 10000 mostly unmapped species of microbes in our guts, who all want different fuels to survive, the amount of interactions between microbe-microbe, microbe-host, host-microbe and feedback loops is so incredibly diverse that it will likely be centuries before we understand it in any detail.

https://pubmed.ncbi.nlm.nih.gov/31539500/

https://www.nature.com/articles/s41467-020-18476-8

https://journals.sagepub.com/doi/10.1177/1178646920928984

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954203/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892391/

https://pubmed.ncbi.nlm.nih.gov/32651764/

https://www.nature.com/articles/s41467-020-16431-1

https://sarahs-world.blog/phages-protect-bacteria/

https://www.nature.com/articles/s41591-019-0559-3

https://www.nature.com/articles/s41592-018-0301-y

https://www.eurekalert.org/pub_releases/2019-02/cwru-nc022119.php

https://naturemicrobiologycommunity.nature.com/users/196886-mathias-l-richard/posts/41608-fungi-and-bacteria-crosstalk-in-the-gut-microbiota-influence-susceptibility-to-inflammation?utm_source=share&utm_medium=ios_app

and there are other players involved, like the virome
https://journals.sagepub.com/doi/full/10.1177/1756284819836620

Gut bacteria have a direct line to the brain -https://medicalxpress.com/news/2020-07-bacteria-gut-line-brain.html

https://www.sciencedirect.com/science/article/abs/pii/S0920996420300864

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00881-2

https://pubmed.ncbi.nlm.nih.gov/32671421/

https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-020-00583-3

https://medicalxpress.com/news/2020-07-antibiotics-disrupt-social-brain-mice.html

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00884-z

https://newatlas.com/fecal-transplants-autism-symptoms-reduction/59278/

https://www.eurekalert.org/pub_releases/2019-04/asu-asr040819.php

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067576/

https://www.sciencemag.org/news/2020/05/meet-psychobiome-gut-bacteria-may-alter-how-you-think-feel-and-act

https://medicalxpress.com/news/2020-05-patients-hemorrhagic-brain-disease-disordered.html

https://onlinelibrary.wiley.com/doi/full/10.1111/brv.12603

https://www.nature.com/articles/s41467-020-15457-9

https://www.eurekalert.org/pub_releases/2020-09/elu-gmc090220.php

https://www.psychologytoday.com/us/blog/the-athletes-way/201910/the-vagus-nerve-may-carry-serotonin-along-the-gut-brain-axis

https://www.psychologytoday.com/au/blog/neuronarrative/201906/could-stress-turn-our-gut-bacteria-against-us

https://www.nature.com/articles/d41586-019-03114-1

https://onlinelibrary.wiley.com/doi/10.1002/da.23045

Gut mucus for brain disorders -
https://www.sciencedaily.com/releases/2020/05/200529093129.htm

Our brains even have a microbiome - https://www.theepochtimes.com/unexpected-evidence-of-a-brain-microbiome_2980770.html

Cooking food and additives changes the microbiome - https://www.sciencedaily.com/releases/2019/09/190930114546.htm

https://news.harvard.edu/gazette/story/2019/10/study-finds-gut-microbes-adapt-quickly-to-changes-in-food-preparation/

https://newatlas.com/health-wellbeing/e171-food-additive-gut-microbiome-inflammation-titanium-dioxide-nanoparticles/

https://www.sciencedirect.com/science/article/abs/pii/S0924224419309902

https://www.nature.com/articles/s41598-020-61192-y

https://academic.oup.com/advances/article/10/suppl_1/S31/5307224

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893834/

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30048-2

https://pubmed.ncbi.nlm.nih.gov/16277764/

Relationship to drugs - https://www.nature.com/articles/d41586-020-00196-0

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597605/

https://chemistry.harvard.edu/news/gut-microbes-eat-our-medication

https://www.sciencedirect.com/science/article/pii/S1931312819303002

https://www.ncbi.nlm.nih.gov/pubmed/31344423/

Eating behaviour is influenced / controlled by gut microbes - https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.201400071

Control our metabolism, ageing and growth -

https://www.nytimes.com/2020/07/22/health/microbiome-malnourishment-children.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705322/

https://www.frontiersin.org/articles/10.3389/fendo.2019.00029/full

https://www.sciencedaily.com/releases/2020/02/200212150158.htm

https://ard.bmj.com/content/79/5/646

https://link.springer.com/article/10.1007/s00280-020-04060-w

https://www.mdpi.com/2072-6643/12/5/1451

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30059-0

https://scitechdaily.com/researchers-find-gut-enzyme-that-helps-prevent-aging-and-frailty/

https://www.pnas.org/content/116/40/19802

https://www.nature.com/articles/s41586-019-1608-2

https://www.news-medical.net/news/20190918/Gut-bacteria-linked-to-stronger-muscles-in-older-people.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115465/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045147/

https://stm.sciencemag.org/content/11/496/eaav1892.full

https://stm.sciencemag.org/content/11/502/eaan5662?utm_source=share&utm_medium=ios_app

and methylation - https://www.nature.com/articles/s41564-019-0659-3

Protect our organs and control their efficiency -

https://www.medicalnewstoday.com/articles/gut-bug-may-help-prevent-heart-disease-and-promote-longevity

https://www.sciencedirect.com/science/article/abs/pii/S1931312820303036

https://www.fightaging.org/archives/2020/07/the-aging-gut-microbiome-produces-more-trimethylamine-harming-arterial-function/

https://www.eurekalert.org/pub_releases/2020-06/hu-mmm061720.php

https://www.liveplanetnews.com/a-new-study-found-fecal-transplant-as-a-promising-treatment-for-non-alcoholic-fatty-liver-disease/

https://www.sciencedaily.com/releases/2020/06/200611152451.htm

https://www.sciencedaily.com/releases/2020/05/200504114124.htm

https://www.eurekalert.org/pub_releases/2020-04/cfdd-acf041420.php

https://www.ncbi.nlm.nih.gov/pubmed/25223989/

https://newatlas.com/science/gut-bacteria-metabolites-microbiome-ulcerative-colitis-inflammation/

https://www.nature.com/articles/s41591-019-0485-4

Acne -

https://link.springer.com/article/10.1007/s40257-020-00531-1

and are inherited from our parents

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235223

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00839-4

https://www.frontiersin.org/articles/10.3389/fmicb.2019.01124/full?utm_source=share&utm_medium=ios_app

At this point, the smartest thing humans can do is say “we now know just enough to know how little we know” and throw in towel, for now. At which point, the question then becomes “at a macro level, how was this whole system supposed to work, before we started fucking with it and breaking things?”

Fortunately, we have some very good examples of that - both the animal kingdom and third world countries, where autoimmune diseases and allergies are virtually non-existent, unlike western society. 😂

https://www.scientificamerican.com/article/gut-microbes-may-be-key-to-solving-food-allergies/

https://fxmed.co.nz/why-are-allergies-and-autoimmune-diseases-increasing-in-developed-countries/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841828/

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30103-9?d

Zonulin -

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384703/

Coeliac disease controlled by oral bacteria -
https://www.sciencedaily.com/releases/2016/09/160906085840.htm

Peanut allergy -

https://www.ajmc.com/conferences/aaaai-20/qa-can-a-plant-compound-impact-interaction-between-food-allergy-microbiome

The common link is the connection with the environment and specifically the microbiome..

Dirt - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780873/

https://www.researchgate.net/publication/5661381_Geophagy_soil_consumption_enhances_the_bioactivities_of_plants_eaten_by_chimpanzees

https://qz.com/993258/dirt-has-a-microbiome-and-it-may-double-as-an-antidepressant/

https://www.sciencealert.com/daycares-in-finland-built-a-backyard-forest-and-it-changed-children-s-immune-systems/amp
(Study)
https://advances.sciencemag.org/content/6/42/eaba2578

It’s really interesting - you can look at the microbiome population diversity in people and animals and you’ll see that the “fingerprint” matches what you see in the soil. You can even identify what country someone is from by examining their stool and comparing it to soil samples.

Plants have a microbiome of their own, too -
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265069/

Western society has disconnected from the naturally evolved microbiome lifecycle.

Regular dietary intake of diverse bacterial species, as transported on raw, unwashed, organic food items that are already favourable to those microbes present appear to be the natural mechanism for maintaining gut health.

Being active in a natural environment with regular exposure to dirt, plants and regular hand/mouth interactions is another mechanism to facilitate microbial diversity maintenance.

Without this simple mechanism, we’re left to turn to faecal microbiome transplants as tools to mediate and resolve gut dysbiosis, allergies, disorders and disease progression.


Ultimately, it boils down to one unpleasant question - for chronic disease prevention, do you prefer to eat trace amounts of dirt in your unwashed food, or eat crapsules full of human shit? 😁