Can you be more specific?
Skyrim works but FO4 doesn't. Using Windows 8 with updates up to July, here's a list of currently running processes.

ProcessName        Description
-----------        -----------
audiodg            Windows Audio Device Graph Isolation
chrome             Google Chrome
ClassicStartMenu   Classic Start Menu
csrss              Client Server Runtime Process
csrss              Client Server Runtime Process
dasHost            Device Association Framework Provider Host
dwm                Desktop Window Manager
explorer           Windows Explorer
HeciServer         Intel(R) Capability Licensing Service Interface
Idle               Percentage of time the processor is idle
lsass              Local Security Authority Process
OVRRedir           OVRRedir.exe
OVRServer_x64      OVRServer_x64.exe 442311 -public ...
OVRServiceLauncher OVR Service Launcher
SearchIndexer      Microsoft Windows Search Indexer
services           Services and Controller app
smss               Windows Session Manager
svchost            Host Process for Windows Services
System             NT Kernel & System
taskhost           Host Process for Windows Tasks
taskhostex         Host Process for Windows Tasks
vorpControl        vorpX VR Driver Control
vorpControl64.dat  vorpX VR Driver Control
wininit            Windows Start-Up Application
winlogon           Windows Logon Application
WUDFHost           Windows Driver Foundation - User-mode Driver Framework Host Process