<?php
define('SHORTINIT', true);
require '/path/to/wp-load.php';
// you'll have the basic API here, including `get_option`. Do stuff.

// EXAMPLE
function MyFuncion(){
    if (isset($_POST['mynamee'])) { echo get_option('my_nm');}
}

//===================Then====================
//1) Execute directly
MyFunction();
//========OR=========
//2) Hook into the EARLIEST ACTION:
add_action('muplugins_loaded', 'MyFunction',1);