Searching/reading another file from awk based on current file's contents, is it possible?

f1 f2 f3 f4 f5
X  Y  Z  A  B

f1 f2 f3 f4
A  U  B  W

#!/usr/bin/env perl -nwa
use strict;
use File::Find 'find';
my @search = qw(X Y Z);

# if you know in advance that the otherfile isn't
# huge, you can cache it in memory as an optimization.

# with any more columns, you want a loop here:
if ($F[0] eq $search[0]
    and $F[1] eq $search[1]
    and $F[2] eq $search[2])
{
  my @files;
  find(sub {
      return if not -f $_;
      # verbatim search for the columns in the file name.
      # I'm still not sure what your file-search criteria are, though.
      push @files, $File::Find::name if /Q$F[3]E/ and /Q$F[4]E/;
      # alternatively search for the combination:
      #push @files, $File::Find::name if /Q$F[3]E.*Q$F[4]E/;
      # or search *all* files in the search path?
      #push @files, $File::Find::name;
    }, '/search/path'
  )
  foreach my $file (@files) {
    open my $fh, '<', $file or die "Can't open file '$file': $!";
    while (defined($_ = <$fh>)) {
      chomp;
      # order of fields doesn't matter per your requirement.
      my @cols = split ' ', $_;
      my %seen = map {($_=>1)} @cols;
      if ($seen{$F[3]} and $seen{$F[4]}) {
        print join(' ', $F[0], @cols[1,2]), "n";
      }
    }
    close $fh;
  }
} # end if matching line

## perl code to do some dirty work

for my $line (`grep 'X Y Z' myhugefile`) {
    chomp $line;
    my ($a, $b, $c, $d, $e) = split(/ /,$line);
    my $cmd = 'grep -P "' . $d . ' .+? ' . $e .'" otherfile';
    for my $from_otherfile (`$cmd`) {
        chomp $from_otherfile;
        my ($oa, $ob, $oc, $od) = split(/ /,$from_otherfile);
        print "$a $ob $ocn";
    }
}