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5-HTP Supplementation

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Dec 16th, 2015
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  1. 5-HTP
  3. Dose
  4. Light Theraputic (anxiety): 50mg-100mg Common Theraputic (sleep): 100mg-200mg Recovery Dose (ie comedown of MDMA) 200-300mg (excess of 300mg
  6. Duration
  7. 4-6 hours
  9. Onset
  10. 30-60 minutes
  12. Effects
  13. Mood Stabilization, Euphoria, sleep aid, antidepressant, appetite suppressant, possible nausea
  15. Avoid
  16. Anything that interacts with serotonin levels or is serotonergic including SSRIs, MAOIs (in large doses), DXM, MDMA (during or before)
  18. Aliases
  19. 5HTP
  20. 5-Hydroxytryptophan
  21. Tryptophan
  22. L-Tryptophan
  23. oxitriptan
  25. Summary
  26. An amino acid that is the precursor to serotonin. 5-HTP is sold over the counter in the United Kingdom, the United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. It is also useful in the recovery from certain psychedelics that drain serotonin such as MDMA (See ~drugs 5-HTP MDMA
  28. Categories
  29. Mood stabilizer, Anti-depressant, recovery
  31. Half Life
  32. The biological half-life of 5-HTP ranged from 2.2 to 7.4 hours, and the plasma clearance ranged from 0.10 to 0.23 1/kg/hour
  34. After-Effects
  35. Minimal, slight depression/anxiety after repeated use
  37. MDMA
  38. MDMA and 5-HTP are dangerous when done at the same time. However, 5-HTP can mean a world of difference for recovering from MDMA and other drugs.
  40. One must use 5-HTP AFTER your MDMA high fades and the dysphoric comdown begins. Wait AT LEAST 5-6 hours after the last dose of MDMA.
  42. The basis for doing this is that 5-HTP is a necessary precursor for the brain to produce more serotonin, and MDMA use depletes a person's natural serotonin levels, thus taking 5-HTP after consuming MDMA is speculated as helping improve serotonin production.
  44. 5-HTP should be taken with EGCCG(Green Tea Extract). EGCG paired with 5-HTP promoted accumulation of serotonin in the brain instead of the periphery. This is important because free 5-HTP in the bloodstream and cause cardiovascular complications.
  46. See section 5.2 :
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