Isaac and Naito Zivaku land in Pandora's Temple of God of War I, along with Cheryl "Heather" Mason and Audrey Jones, near the very end of that dungeon. After some conversations about their reunions, including Cheryl meeting with Isaac for the first time in a while, and Isaac berating Naito about his hesitance to date the Sneaselmorph Jasmine in spite of his own bizarre genetics, all of them are killed when Ares murders Kratos and steals Pandora's Box. Isaac, before his death, is given a deal with Thanatos, the ancient God of Death, providing him with his Brimstone Magic courtesy of the Sisters of Fate, but dies anyway. The quartet journeys with Kratos through the Path of Hades, a section of the Underworld, before being released by Zeus in the guise of the Gravedigger (only known to be as such by Isaac and Audrey). When Kratos goes off to fight Ares (uncaring of the Interferences' plights), the Zivaku men carry the women to the sword-bridge known as the Blade of the Gods, where they take part in the fight against Atropos, one of the Sisters of Fate from years down the line, with a future Kratos (from near the end of God of War II). Upon defeating both her and Lahkesis, including a trip through a temporal portal, and with the aid of Sora, who had been fighting Lahkesis in the meantime, they complete their goal, with Isaac severing one of Atropos' portal-making hands and keeping it for limited time travel opportunities. Sora reveals the death of Greg, Naito's father, to him, resulting in him running off to find ohter worlds. Despite his anger with Isaac for not saying anything, Sora agrees with Isaac and Audrey's analyses that he should find Jasmine, going on their description of her as he leaves the world, with Cheryl, Isaac, and Audrey following soon afterwards.