RNA-targeting compound restarts a healing factor silenced by heart attack



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RNA-targeting compound restarts a healing factor silenced by heart attack
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Reviewed by Emily Henderson, B.Sc.Aug 24 2020
A heart attack can leave parts of the heart permanently scarred and stiff, resulting in prolonged disability and potential progression toward heart failure. Scientists have studied various ways to repair or regenerate such damaged heart tissue, with limited success.

A new study from Scripps Research Chemist Matthew Disney, PhD, shows that by targeting an essential biomolecule that surges in failing heart muscle, it may be possible to one day heal damaged heart tissue with medication.

In a study published Monday in the journal Nature Chemistry, the Disney collaboration describes the discovery of the first compounds able to restart cellular production of a factor called VEGF-A, short for vascular endothelial growth factor A, in cellular models.
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