Pre-COVID-19 coronavirus antibodies fail to neutralize SARS-CoV-2

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Pre-COVID-19 coronavirus antibodies fail to neutralize SARS-CoV-2
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Sally Robertson, B.Sc.
By Sally Robertson, B.Sc.Aug 2 2020
Researchers in Austria have shown that antibodies with potent neutralizing activity against a well-established seasonal coronavirus had no neutralizing activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

The team carried out the study to test whether SARS-CoV-2 could potentially be neutralized by antibodies induced by seasonal coronaviruses that are already circulating.

The analysis of intravenous immunoglobulin (IVIG) lots produced against human coronavirus (hCoV) 299E, a long-recognized cause of the common cold, showed high titers of neutralizing antibodies (nAbs) against the 299E virus, but no cross-neutralization effect against SARS-CoV-2.

Thomas Kreil and colleagues from Baxter AG, Vienna, say the finding suggests that nAbs against well-known seasonal coronaviruses cannot neutralize SARS-CoV-2 and that the currently available IVIG lots would not offer any protection against the virus.
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