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//#############################index.html
...
<body>
<script data-main="requirejs-config.js" src="js/require.js"></script>
<script> require(['requirejs-config.js'], function(){}); </script>
<script src="js/app.js"></script>
</body>
...

//#############################require-config.js
requirejs.config({
  baseUrl: 'node_modules',
  paths: {
    jquery : "jquery.min.js",
    handlebars : "handlebars.min.js",
    underscore: 'underscore-min.js',
    backbone : "backbone-min.js",
    marionette : "backbone.marionette.min.js"

  },
  shim: {
    "backbone": [
      "underscore",
      "jquery"
    ],
    "marionette": [
      "backbone.wreqr",
      "backbone.babysitter"
    ]
  }
});

//################################app.js
define(['jquery', 'underscore', 'backbone', 'marionette'], function ($, _, Backbone, Marionette) {
  var app = app || {};

  $(function() {
    return new app.PostView({model: app.Posts()});
  });
});