array(2) {
    ["area1"] => array(3) {
        [0] => string(5) "item1"
        [1] => string(5) "item2"
        [2] => string(5) "item3"
    }
    ["area2"] => array(2) {
        [0] => string(5) "item1"
        [1]=> string(5) "item2"}
    }
}

"select nombre, tipo from tabla1 where area1 in(item1, item2, item3) and area2 in (item1, item2)"

$array = array("area1"=> array("item1","item2","item1") , "area2"=> array("item1","item2"));
$area1 = "'".implode("','", $array['area1'])."'";
/* Convertimos a String ,separado por comas*/
$area2 =  "'".implode("','", $array['area2'])."'";
$sentencia = $mbd->prepare("SELECT nombre,tipo from tabla1 where area1 in  ( $area1 )
                            and area2 in ($area2)"); /* Le pasamos la colección*/
$sentencia->execute(); /* Ejecutamos la Sentencia */
$fila = $sentencia->fetchAll();
print_r($fila);

$paramsIn1 = [10, 203, 4, 6];
$paramsIn2 = [10, 203];

$strParams1 = implode(',', array_fill(0, count($paramsIn1), '?'));
$strParams2 = implode(',', array_fill(0, count($paramsIn2), '?'));

$sqlQuery = "select nombre,tipo from tabla1 where area1 in($strParams1) and area2 in ($strParams2)";

$sth      = $dbh->prepare($sqlQuery);
$sth->execute(
    array_merge(
        $paramsIn1, $paramsIn2
    )
);

public function procesarDestinatarios($array){
    $consulta = "select nombre,tipo from datosusuarios where ";


    $aux1 = 1;
    $aux2 = 1;

    $count1 = count($array);
    $count2 = 0;

    foreach ($array as $key => $value) {
        $count2 = count($array[$key]);
        $consulta .= $key ." in (";

        foreach ($value as $valor) {
            if($aux2 < $count2){
                $consulta .= "'".$valor ."',";
                $aux2++;
            }else{
                $consulta .= "'".$valor."'";
                $aux2 = 1;
            }

        }

        if($aux1 < $count1){
            $consulta .= ") and ";
        }else{
            $consulta .= ")";
        }

        $aux1++;
    }

    return $consulta;

}

select nombre,tipo from datosusuarios where area1 in ('zona2','zona3') and grupo in ('a','c','d','h')