from direct.showbase.ShowBase import ShowBase
from panda3d.core import WindowProperties

class MyApp(ShowBase):
    def __init__(self):
        ShowBase.__init__(self)
        self.disableMouse()
        props = WindowProperties()
        props.setMouseMode(WindowProperties.M_relative)
        base.win.requestProperties(props)

app = MyApp()
app.run()