Apoptosis In Toxicology

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Deals with basic mechanisms of apoptosis and their relevance to toxicology, and highlights the importance of apoptosis in various tissues in response to toxic agents. Focuses on molecular regulation of apoptosis with particular emphasis on toxicant action, addressing cell survival signalling and its perturbation at the genetic and biochemical level, and looking at aspects including key survival and death genes, survival signaling, commitment to apoptosis, and recruitment of the initiator and executioner caspases. Methods that can be employed to quantify apoptosis are compared and their applica...