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- Melee Only Survival Permadeath
- Rules: No VATS, Power Armor, Slow-time Jet, or Yao Guai Roast
- S - 6
- P - 1
- E - 10 (+1 sanctuary book. Must be over-encumbered to reduce END)
- C - 3
- I - 6
- A - 1
- L - 1
- Leveling Guide:
- 2. Lone Wanderer
- 3. Aqua Girl
- 4. (get INT bobblehead) Chemist
- 5. Lifegiver
- 6. Big Leagues
- 7. Strength+ (7)
- 8. Lifegiver II
- 9. Strength+ (8)
- 10. Adamantium Skeleton
- 11. Big Leagues II
- 12. Science
- 13. Adamantium Skeleton II
- 14. Blacksmith
- 15. (save point for lvl 17)
- 16. Blacksmith II
- 17. Lone Wanderer II, Science II
- 18. Strength+ (9)
- 19. Chemist II
- 20. Life Giver III
- 21. Rooted
- 22. Rooted II
- 23. Armorer
- 24. Armorer II
- 25. Armorer III
- 26. Adamantium Skeleton III
- 27. Big Leagues III
- 28. Science III
- 29. Big Leagues IV
- 30. Blacksmith III
- 31. Strength+ (10)
- 32. Chemist III
- 33. Solar Powered
- 34. Solar Powered II
- 35. Medic
- 36. Medic II
- 37. Medic III
- 38. Hacker
- 39. Armorer IV
- 40. Lone Wanderer III
- 41. Science IV
- 42. Big Leagues V
- 43. Hacker II
- 44. Hacker III
- 45. Chemist IV
- 46. Ghoulish
- 47. Ghoulish II
- 48. Ghoulish III
- 49. Medic IV
- 50. Solar Powered III
- 51. Ghoulish IV
- After Level 50 Perks:
- Toughness
- Bloody Mess
- Nerd Rage
- Strong Back
- Endgame Gear:
- Movement Speed Outfit:
- Armored Army Fatigues
- The Captain's Hat
- Black Ops Chest (biocom mesh mod)
- Recon Marine Right Arm
- Champion Left Arm (dense mod)
- Black Ops Right Shin Guard
- Destroyer's Left Leg
- Road Goggles
- Combat Outfit:
- Armored Army Fatigues
- Green Rag Hat (armored)
- Recon Marine Chest (dense mod)
- Overseer's Right Arm
- Recon Marine Left Arm
- Black Ops Right Shin Guard
- Destroyer's Left Leg (or any other applicable legendary leg armor, depending on the situation)
- Road Goggles
- Exp Outfit (for turning in quests):
- Lab Coat
- The Captain's Hat
- Road Goggles
- Charisma Outfit:
- Agatha's Dress
- Dapper Gent
- Black-rimmed glasses
- Weapon Slots:
- 1 - Instigating Disciples Cutlass
- 2 - The Harvester
- 3 - Fencebuster
- Chems/Consumables to take for combat:
- Bufftats
- Psychobuff
- Overdrive
- Fury
- Med-X
- Mysterious Serum
- Grilled Hermit Crab
- Grilled Queen Nukalurk
- Mirelurk Queen Steak
- Yao Guai Ribs
- Against Energy Weapons:
- Crispy Cave Cricket
- Radscorpion Steak
- Radstag Stew
- Important Collectibles/Other Perks:
- Grognak Magazine x10
- Melee Bobblehead
- Endurance Bobblehead
- Strength Bobblehead (collect after reaching STR 10)
- Charisma Bobblehead
- Unstopables Magazine x5
- SCAV #2 (+25% knife damage)
- SCAV #5 (+STR and END the less caps you have, up to +3 each at less than 100 caps)
- Astoundingly Awesome Tales - My Brain and I... (health regen mag)
- Astoundingly Awesome Tales #4 (+5 poison resistance)
- Total Hack #3 (control turrets)
- Pack Alpha perk
- Chosen Disciple perk
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