Item[KeyEvent["q", Modifiers -> {Control, Option}],
           FrontEndExecute[
                   FrontEndToken[
                            SelectedNotebook[ ],
                            "EvaluatorQuit",
                            Automatic
                   ]
           ]
   ]

Item[KeyEvent["i", Modifiers -> {Command, Control}],
           FrontEndExecute[
                   FrontEndToken[
                           SelectedNotebook[ ],
                           "InitializationCell",
                           "Toggle"
                   ]
           ]
   ]

Item[
    KeyEvent["i", Modifiers -> {Control, Command}],
    FrontEndExecute[
        FrontEnd`SetOptions[FrontEnd`NotebookSelection[], InitializationCell->Toggle]
    ]
]