from six.moves.urllib.parse import quote
import requests

req = requests.session()
params={'_': '1516602174329', 'ex_ch': 'tse_2330.tw|tse_1101.tw'}
quote_params = { key: quote(value) for key, value in params.items() }
req.get('http://mis.twse.com.tw/stock/index.jsp') # get cookie
response = req.get('http://mis.twse.com.tw/stock/api/getStockInfo.jsp', params=quote_params)
print(response.text)