iface enp0s25 inet static
address 10.10.8.2
netmask 255.255.0.0
gateway 10.10.1.1
dns-nameservers 8.8.8.8 8.8.4.4

#dns=dnsmasq (comment out the dnsmasq)
[ifupdown]
managed=true (changed from false)

sudo nano /etc/network/interfaces

auto enp0s25
iface enp0s25 inet static
address 192.168.0.16
netmask 255.255.255.0
gateway 192.168.0.1
dns-nameservers 8.8.4.4 8.8.8.8

/etc/netplan/50-cloud-init.yaml

network:
    ethernets:
        enp0s3:
            addresses: [192.168.0.55/24]
            gateway4: 192.168.0.1
            dhcp4: no
            nameservers:
              addresses: [1.1.1.1,8.8.8.8]
            optional: true
    version: 2

sudo ip addr flush enp0s25
sudo systemctl restart networking.service

ip add

auto lo
    iface lo inet loopback
    auto eth0
    iface eth0 inet static
    address 192.168.1.10
    gateway 192.168.1.1
    netmask 255.255.255.0
    dns-nameservers 8.8.8.8

# interfaces(5) file used by ifup(8) and ifdown(8)
# auto lo
# iface lo inet loopback
auto enp2s0
iface enp2s0 inet static
    address 172.16.9.124
    netmask 255.255.240.0
    gateway 172.16.0.9
dns-nameservers 8.8.8.8

auto ens160
iface ens160 inet static
address 172.31.0.164/22
netmask 255.255.252.0
gateway 172.31.0.2
network 172.31.0.0
broadcast 172.31.3.255
dns-nameservers 172.31.0.21 172.31.0.18

#Add internal route
up route add -net 172.16.168.0/21 gw 172.31.0.20 dev ens160

~$ touch /etc/network/interfaces.d/ens160