$stmt=$pdo->prepare('INSERT INTO t(c1,c2,c3) VALUES(?,?,?)');
$stmt->execute([9876543210,9876543210,9876543210]);

$sql='INSERT INTO t(pk,c1,c2) VALUES(?,?,?), (?,?,?), (?,?,?)
ON DUPLICATE KEY UPDATE c1=VALUES(c1),c2=VALUES(c2)';
$stmt=$pdo->prepare($sql);
$stmt->execute([1,111,111,2,222,222,3,333,333]);