RewriteCond %{REQUEST_FILENAME} !-f
RewriteCond %{REQUEST_FILENAME} !-d
RewriteCond %{REQUEST_URI} !=/favicon.ico
RewriteRule ^ index.php [L]

if (strpos(request_uri(), '?q=') !== FALSE) {

<VirtualHost *:80>
    ServerAdmin webmaster@mydomain.com
    DocumentRoot /var/www/mydomain.com/
    ServerName www.mydomain.com
    ServerAlias *.mydomain.com mydomain.com
    UseCanonicalName On
    ErrorLog logs/mydomain.com.err
    CustomLog logs/mydomain.com common
</VirtualHost>

<VirtualHost *:443>
    ServerAdmin webmaster@mydomain.com
    DocumentRoot /var/www/mydomain.com/
    ServerName www.mydomain.com
    ServerAlias *.mydomain.com mydomain.com
    UseCanonicalName On
    ErrorLog logs/mydomain.com.err
    CustomLog logs/mydomain.com common
</VirtualHost>


<Directory /var/www/mydomain.com/>
   RewriteEngine on
   RewriteBase /
   RewriteCond %{REQUEST_FILENAME} !-f
   RewriteCond %{REQUEST_FILENAME} !-d
   RewriteRule ^(.*)$ index.php?q=$1 [L,QSA]
</Directory>

<VirtualHost *:80>
    ServerAdmin webmaster@mydomain.com
    DocumentRoot /var/www/second_domain.mydomain.com/
    ServerName second_domain.mydomain.com
    ServerAlias *.second_domain.mydomain.com
    UseCanonicalName On
    ErrorLog logs/second_domain.mydomain.com.err
    CustomLog logs/second_domain.mydomain.com common
</VirtualHost>

<VirtualHost *:443>
    ServerAdmin webmaster@mydomain.com
    DocumentRoot /var/www/second_domain.mydomain.com/
    ServerName second_domain.mydomain.com
    ServerAlias *.second_domain.mydomain.com
    UseCanonicalName On
    ErrorLog logs/second_domain.mydomain.com.err
    CustomLog logs/second_domain.mydomain.com common
</VirtualHost>


<Directory /var/www/second_domain.mydomain.com/>
   RewriteEngine on
   RewriteBase /
   RewriteCond %{REQUEST_FILENAME} !-f
   RewriteCond %{REQUEST_FILENAME} !-d
   RewriteRule ^(.*)$ index.php?q=$1 [L,QSA]
</Directory>

$request = drupal_http_request($GLOBALS['base_url'] . '/admin/config/search/clean-urls/check');