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  1. iterate at ./compiler/ssair/ir.jl:1133
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  130. iterate at ./compiler/ssair/ir.jl:1133
  131. iterate at ./compiler/ssair/ir.jl:1133
  132. iterate at ./compiler/ssair/ir.jl:1133
  133. iterate at ./compiler/ssair/ir.jl:1133
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  135. iterate at ./compiler/ssair/ir.jl:1133
  136. iterate at ./compiler/ssair/ir.jl:1133
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  138. iterate at ./compiler/ssair/ir.jl:1133
  139. iterate at ./compiler/ssair/ir.jl:1133
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  143. iterate at ./compiler/ssair/ir.jl:1133
  144. iterate at ./compiler/ssair/ir.jl:1133
  145. iterate at ./compiler/ssair/ir.jl:1133
  146. iterate at ./compiler/ssair/ir.jl:1133
  147. iterate at ./compiler/ssair/ir.jl:1133
  148. iterate at ./compiler/ssair/ir.jl:1133
  149. iterate at ./compiler/ssair/ir.jl:1133
  150. iterate at ./compiler/ssair/ir.jl:1133
  151. iterate at ./compiler/ssair/ir.jl:1133
  152. iterate at ./compiler/ssair/ir.jl:1133
  153. iterate at ./compiler/ssair/ir.jl:1133
  154. iterate at ./compiler/ssair/ir.jl:1133
  155. iterate at ./compiler/ssair/ir.jl:1133
  156. getfield_elim_pass! at ./compiler/ssair/passes.jl:694
  157. run_passes at ./compiler/ssair/driver.jl:123
  158. optimize at ./compiler/optimize.jl:164
  159. typeinf at ./compiler/typeinfer.jl:35
  160. typeinf_edge at ./compiler/typeinfer.jl:497
  161. abstract_call_method at ./compiler/abstractinterpretation.jl:345
  162. abstract_call_gf_by_type at ./compiler/abstractinterpretation.jl:85
  163. abstract_call at ./compiler/abstractinterpretation.jl:776
  164. abstract_eval_call at ./compiler/abstractinterpretation.jl:805
  165. abstract_eval at ./compiler/abstractinterpretation.jl:890
  166. typeinf_local at ./compiler/abstractinterpretation.jl:1121
  167. typeinf_nocycle at ./compiler/abstractinterpretation.jl:1191
  168. typeinf at ./compiler/typeinfer.jl:14
  169. typeinf_edge at ./compiler/typeinfer.jl:497
  170. abstract_call_method at ./compiler/abstractinterpretation.jl:345
  171. abstract_call_gf_by_type at ./compiler/abstractinterpretation.jl:85
  172. abstract_call at ./compiler/abstractinterpretation.jl:776
  173. abstract_eval_call at ./compiler/abstractinterpretation.jl:805
  174. abstract_eval at ./compiler/abstractinterpretation.jl:890
  175. typeinf_local at ./compiler/abstractinterpretation.jl:1135
  176. typeinf_nocycle at ./compiler/abstractinterpretation.jl:1191
  177. typeinf at ./compiler/typeinfer.jl:14
  178. typeinf_edge at ./compiler/typeinfer.jl:497
  179. abstract_call_method at ./compiler/abstractinterpretation.jl:345
  180. abstract_call_gf_by_type at ./compiler/abstractinterpretation.jl:85
  181. abstract_call at ./compiler/abstractinterpretation.jl:776
  182. abstract_eval_call at ./compiler/abstractinterpretation.jl:805
  183. abstract_eval at ./compiler/abstractinterpretation.jl:890
  184. typeinf_local at ./compiler/abstractinterpretation.jl:1135
  185. typeinf_nocycle at ./compiler/abstractinterpretation.jl:1191
  186. typeinf at ./compiler/typeinfer.jl:14
  187. typeinf_edge at ./compiler/typeinfer.jl:497
  188. abstract_call_method at ./compiler/abstractinterpretation.jl:345
  189. abstract_call_gf_by_type at ./compiler/abstractinterpretation.jl:85
  190. abstract_call at ./compiler/abstractinterpretation.jl:776
  191. abstract_apply at ./compiler/abstractinterpretation.jl:519
  192. abstract_call at ./compiler/abstractinterpretation.jl:567
  193. abstract_eval_call at ./compiler/abstractinterpretation.jl:805
  194. abstract_eval at ./compiler/abstractinterpretation.jl:890
  195. typeinf_local at ./compiler/abstractinterpretation.jl:1135
  196. typeinf_nocycle at ./compiler/abstractinterpretation.jl:1191
  197. typeinf at ./compiler/typeinfer.jl:14
  198. typeinf_edge at ./compiler/typeinfer.jl:497
  199. abstract_call_method at ./compiler/abstractinterpretation.jl:345
  200. abstract_call_gf_by_type at ./compiler/abstractinterpretation.jl:85
  201. return_type_tfunc at ./compiler/tfuncs.jl:1337
  202. abstract_call at ./compiler/abstractinterpretation.jl:722
  203. abstract_eval_call at ./compiler/abstractinterpretation.jl:805
  204. abstract_eval at ./compiler/abstractinterpretation.jl:890
  205. typeinf_local at ./compiler/abstractinterpretation.jl:1135
  206. typeinf_nocycle at ./compiler/abstractinterpretation.jl:1191
  207. typeinf at ./compiler/typeinfer.jl:14
  208. typeinf_edge at ./compiler/typeinfer.jl:497
  209. abstract_call_method at ./compiler/abstractinterpretation.jl:345
  210. abstract_call_gf_by_type at ./compiler/abstractinterpretation.jl:85
  211. abstract_call at ./compiler/abstractinterpretation.jl:776
  212. abstract_eval_call at ./compiler/abstractinterpretation.jl:805
  213. abstract_eval at ./compiler/abstractinterpretation.jl:890
  214. typeinf_local at ./compiler/abstractinterpretation.jl:1121
  215. typeinf_nocycle at ./compiler/abstractinterpretation.jl:1191
  216. typeinf at ./compiler/typeinfer.jl:14
  217. typeinf_edge at ./compiler/typeinfer.jl:497
  218. abstract_call_method at ./compiler/abstractinterpretation.jl:345
  219. abstract_call_gf_by_type at ./compiler/abstractinterpretation.jl:85
  220. abstract_call at ./compiler/abstractinterpretation.jl:776
  221. abstract_eval_call at ./compiler/abstractinterpretation.jl:805
  222. abstract_eval at ./compiler/abstractinterpretation.jl:890
  223. typeinf_local at ./compiler/abstractinterpretation.jl:1135
  224. typeinf_nocycle at ./compiler/abstractinterpretation.jl:1191
  225. typeinf at ./compiler/typeinfer.jl:14
  226. typeinf_ext at ./compiler/typeinfer.jl:576
  227. typeinf_ext at ./compiler/typeinfer.jl:613
  228. jfptr_typeinf_ext_1.clone_1 at /Applications/Julia-1.1.app/Contents/Resources/julia/lib/julia/sys.dylib (unknown line)
  229. jl_apply_generic at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:2219 [inlined]
  230. jl_apply at /Users/osx/buildbot/slave/package_osx64/build/src/./julia.h:1571 [inlined]
  231. jl_type_infer at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:277
  232. jl_compile_method_internal at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1819
  233. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1863
  234. #conditional_nll_ext#88 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:60
  235. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  236. conditional_nll_ext at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:47 [inlined]
  237. #_mean#136 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:343
  238. unknown function (ip: 0x14635b74b)
  239. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  240. _mean at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:343 [inlined]
  241. #131 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:314 [inlined]
  242. vector_mode_dual_eval at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/apiutils.jl:35 [inlined]
  243. vector_mode_gradient! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/gradient.jl:102
  244. gradient! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/gradient.jl:35 [inlined]
  245. InnerGradientForHess at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:50 [inlined]
  246. vector_mode_dual_eval at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/apiutils.jl:42
  247. vector_mode_jacobian! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/jacobian.jl:163
  248. jacobian! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/jacobian.jl:74
  249. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  250. hessian! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:67
  251. hessian! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:65
  252. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  253. hessian! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:65
  254. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  255. macro expansion at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:332 [inlined]
  256. #ll_derivatives#134 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:326
  257. unknown function (ip: 0x14634ae26)
  258. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  259. ll_derivatives at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:326
  260. unknown function (ip: 0x14634a56b)
  261. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  262. #ll_derivatives#133 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:319
  263. unknown function (ip: 0x14634a40e)
  264. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  265. ll_derivatives at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:319 [inlined]
  266. #140 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:360
  267. _mapreduce at ./reduce.jl:313
  268. unknown function (ip: 0x146347d99)
  269. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  270. _mapreduce_dim at ./reducedim.jl:308
  271. #FIM#139 at ./reducedim.jl:304 [inlined]
  272. FIM at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:357 [inlined]
  273. #marginal_nll#115 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:239
  274. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  275. marginal_nll at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:237 [inlined]
  276. #marginal_nll#121 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:280
  277. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  278. marginal_nll at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:279 [inlined]
  279. #123 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:284 [inlined]
  280. _mapreduce at ./reduce.jl:313
  281. #marginal_nll#122 at ./reducedim.jl:308 [inlined]
  282. marginal_nll at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:284
  283. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  284. #23 at ./none:1
  285. vector_mode_gradient at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/apiutils.jl:35
  286. gradient at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/gradient.jl:17 [inlined]
  287. #94 at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:16 [inlined]
  288. vector_mode_dual_eval at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/apiutils.jl:35
  289. vector_mode_jacobian at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/jacobian.jl:139
  290. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  291. jacobian at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/jacobian.jl:17
  292. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  293. hessian at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:17
  294. hessian at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:15
  295. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  296. hessian at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:15
  297. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  298. do_call at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:323
  299. eval_stmt_value at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:362 [inlined]
  300. eval_body at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:759
  301. jl_interpret_toplevel_thunk_callback at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:885
  302. Interpreter frame (ip: 8)
  303. Core.CodeInfo(code=Array{Any, (10,)}[
  304. Expr(:thunk, Core.CodeInfo(code=Array{Any, (4,)}[
  305. Expr(:global, Symbol("##23#24")),
  306. Expr(:const, Symbol("##23#24")),
  307. Expr(:struct_type, Symbol("##23#24"), Expr(:call, Core.svec), Expr(:call, Core.svec), Core.Function, Expr(:call, Core.svec), false, 0),
  308. Expr(:return, nothing)], codelocs=Array{Int32, (4,)}[1, 1, 1, 1], method_for_inference_limit_heuristics=nothing, ssavaluetypes=4, linetable=Array{Any, (1,)}[Core.LineInfoNode(mod=Main, method=Symbol("top-level scope"), file=:none, line=0, inlined_at=0)], ssaflags=Array{UInt8, (0,)}[], slotflags=Array{UInt8, (0,)}[], slotnames=Array{Any, (0,)}[], inferred=false, inlineable=false, propagate_inbounds=false, pure=false)),
  309. Expr(:call, Core.svec, Symbol("##23#24"), Core.Any),
  310. Expr(:call, Core.svec),
  311. Expr(:call, Core.svec, SSAValue(2), SSAValue(3)),
  312. Expr(:method, false, SSAValue(4), Core.CodeInfo(code=Array{Any, (18,)}[
  313. Expr(:call, Base.getproperty, Main.PuMaS, :(:marginal_nll)),
  314. Expr(:call, Core.tuple, :(:θ₁), :(:θ₂), :(:θ₃), :(:θ₄), :(:Ω), :(:σ_add), :(:σ_prop)),
  315. Expr(:call, Core.apply_type, Core.NamedTuple, SSAValue(2)),
  316. Expr(:call, Base.getindex, Core.SlotNumber(id=2), 1),
  317. Expr(:call, Base.getindex, Core.SlotNumber(id=2), 2),
  318. Expr(:call, Base.getindex, Core.SlotNumber(id=2), 3),
  319. Expr(:call, Base.getindex, Core.SlotNumber(id=2), 4),
  320. Expr(:call, Main.:(:), 5, 6),
  321. Expr(:call, Base.getindex, Core.SlotNumber(id=2), SSAValue(8)),
  322. Expr(:call, Main.PDiagMat, SSAValue(9)),
  323. Expr(:call, Base.getindex, Core.SlotNumber(id=2), 7),
  324. Expr(:call, Base.getindex, Core.SlotNumber(id=2), 8),
  325. Expr(:call, Core.tuple, SSAValue(4), SSAValue(5), SSAValue(6), SSAValue(7), SSAValue(10), SSAValue(11), SSAValue(12)),
  326. Expr(:call, SSAValue(3), SSAValue(13)),
  327. Expr(:call, Base.getproperty, Main.PuMaS, :(:FOCEI)),
  328. Expr(:call, SSAValue(15)),
  329. Expr(:call, SSAValue(1), Main.theopmodel_focei, Main.theopp, SSAValue(14), SSAValue(16)),
  330. Expr(:return, SSAValue(17))], codelocs=Array{Int32, (18,)}[1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1], method_for_inference_limit_heuristics=nothing, ssavaluetypes=18, linetable=Array{Any, (1,)}[Core.LineInfoNode(mod=Main, method=Symbol("#23"), file=:none, line=1, inlined_at=0)], ssaflags=Array{UInt8, (0,)}[], slotflags=Array{UInt8, (2,)}[0x00, 0x00], slotnames=Array{Any, (2,)}[
  331. Symbol("#self#"),
  332. :t], inferred=false, inlineable=false, propagate_inbounds=false, pure=false)),
  333. Expr(:call, Base.getproperty, :ForwardDiff, :(:hessian)),
  334. Core.SlotNumber(id=1) = Expr(:new, Symbol("##23#24")),
  335. Core.SlotNumber(id=1),
  336. Expr(:call, SSAValue(6), SSAValue(8), :tmp),
  337. Expr(:return, SSAValue(9))], codelocs=Array{Int32, (10,)}[1, 1, 1, 1, 1, 1, 1, 1, 1, 1], method_for_inference_limit_heuristics=nothing, ssavaluetypes=10, linetable=Array{Any, (1,)}[Core.LineInfoNode(mod=Main, method=Symbol("top-level scope"), file=:none, line=0, inlined_at=0)], ssaflags=Array{UInt8, (0,)}[], slotflags=Array{UInt8, (1,)}[0x10], slotnames=Array{Any, (1,)}[Symbol("#23")], inferred=false, inlineable=false, propagate_inbounds=false, pure=false)jl_interpret_toplevel_thunk at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:894
  338. jl_toplevel_eval_flex at /Users/osx/buildbot/slave/package_osx64/build/src/toplevel.c:764
  339. jl_toplevel_eval at /Users/osx/buildbot/slave/package_osx64/build/src/toplevel.c:773 [inlined]
  340. jl_toplevel_eval_in at /Users/osx/buildbot/slave/package_osx64/build/src/toplevel.c:793
  341. eval at ./boot.jl:328 [inlined]
  342. repleval at /Users/andreasnoack/.julia/packages/Atom/UtmXq/src/repl.jl:147
  343. #166 at /Users/andreasnoack/.julia/packages/Atom/UtmXq/src/repl.jl:182
  344. with_logstate at ./logging.jl:395
  345. with_logger at ./logging.jl:491 [inlined]
  346. evalrepl at /Users/andreasnoack/.julia/packages/Atom/UtmXq/src/repl.jl:173
  347. do_call at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:323
  348. eval_stmt_value at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:362 [inlined]
  349. eval_body at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:759
  350. jl_interpret_toplevel_thunk_callback at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:885
  351. Interpreter frame (ip: 0)
  352. Core.CodeInfo(code=Array{Any, (2,)}[
  353. Expr(:call, typeof(Atom.evalrepl)(), Main, "ForwardDiff.hessian(t -> PuMaS.marginal_nll(theopmodel_focei, theopp, (θ₁=t[1], θ₂=t[2], θ₃=t[3], θ₄=t[4], Ω=PDiagMat(t[5:6]), σ_add=t[7], σ_prop=t[8]), PuMaS.FOCEI()), tmp)"),
  354. Expr(:return, SSAValue(1))], codelocs=Array{Int32, (2,)}[1, 1], method_for_inference_limit_heuristics=nothing, ssavaluetypes=2, linetable=Array{Any, (1,)}[Core.LineInfoNode(mod=Main, method=Symbol("top-level scope"), file=Symbol("/Users/andreasnoack/.julia/packages/Atom/UtmXq/src/repl.jl"), line=216, inlined_at=0)], ssaflags=Array{UInt8, (0,)}[], slotflags=Array{UInt8, (0,)}[], slotnames=Array{Any, (0,)}[], inferred=false, inlineable=false, propagate_inbounds=false, pure=false)jl_interpret_toplevel_thunk at /Users/osx/buildbot/slave/package_osx64/build/src/interpreter.c:894
  355. jl_toplevel_eval_flex at /Users/osx/buildbot/slave/package_osx64/build/src/toplevel.c:764
  356. jl_toplevel_eval at /Users/osx/buildbot/slave/package_osx64/build/src/toplevel.c:773 [inlined]
  357. jl_toplevel_eval_in at /Users/osx/buildbot/slave/package_osx64/build/src/toplevel.c:793
  358. eval at ./boot.jl:328
  359. eval_user_input at /Users/osx/buildbot/slave/package_osx64/build/usr/share/julia/stdlib/v1.1/REPL/src/REPL.jl:85
  360. run_backend at /Users/andreasnoack/.julia/packages/Revise/yp5KG/src/Revise.jl:769
  361. #58 at ./task.jl:259
  362. jl_fptr_trampoline at /Users/osx/buildbot/slave/package_osx64/build/src/gf.c:1864
  363. jl_apply at /Users/osx/buildbot/slave/package_osx64/build/src/./julia.h:1571 [inlined]
  364. start_task at /Users/osx/buildbot/slave/package_osx64/build/src/task.c:572
  365. ERROR: StackOverflowError:
  366. Stacktrace:
  367. [1] process_node!(::Core.Compiler.IncrementalCompact, ::Array{Any,1}, ::Int64, ::Array{Any,1}, ::Array{Int64,1}, ::Array{Int64,1}, ::Any, ::Int64, ::Int64, ::Int64, ::Bool) at ./compiler/ssair/ir.jl:875
  368. [2] process_node! at ./compiler/ssair/ir.jl:961 [inlined]
  369. [3] iterate(::Core.Compiler.IncrementalCompact, ::Tuple{Int64,Int64}) at ./compiler/ssair/ir.jl:1125
  370. [4] iterate(::Core.Compiler.IncrementalCompact, ::Tuple{Int64,Int64}) at ./compiler/ssair/ir.jl:1133 (repeats 14278 times)
  371. [5] getfield_elim_pass!(::Core.Compiler.IRCode, ::Core.Compiler.DomTree) at ./compiler/ssair/passes.jl:694
  372. [6] run_passes(::Core.CodeInfo, ::Int64, ::Core.Compiler.OptimizationState) at ./compiler/ssair/driver.jl:123
  373. [7] optimize(::Core.Compiler.OptimizationState, ::Any) at ./compiler/optimize.jl:164
  374. [8] typeinf(::Core.Compiler.InferenceState) at ./compiler/typeinfer.jl:35
  375. [9] typeinf_edge(::Method, ::Any, ::Core.SimpleVector, ::Core.Compiler.InferenceState) at ./compiler/typeinfer.jl:497
  376. [10] abstract_call_method(::Method, ::Any, ::Core.SimpleVector, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:345
  377. [11] abstract_call_gf_by_type(::Any, ::Array{Any,1}, ::Any, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:85
  378. [12] abstract_call(::Any, ::Array{Any,1}, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:776
  379. [13] abstract_eval_call(::Array{Any,1}, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:805
  380. [14] abstract_eval(::Any, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:890
  381. [15] typeinf_local(::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:1121
  382. [16] typeinf_nocycle(::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:1191
  383. [17] typeinf(::Core.Compiler.InferenceState) at ./compiler/typeinfer.jl:14
  384. [18] typeinf_edge(::Method, ::Any, ::Core.SimpleVector, ::Core.Compiler.InferenceState) at ./compiler/typeinfer.jl:497
  385. [19] abstract_call_method(::Method, ::Any, ::Core.SimpleVector, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:345
  386. [20] abstract_call_gf_by_type(::Any, ::Array{Any,1}, ::Any, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:85
  387. [21] abstract_call(::Any, ::Array{Any,1}, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:776
  388. [22] abstract_eval_call(::Array{Any,1}, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:805
  389. [23] abstract_eval(::Any, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:890
  390. [24] typeinf_local(::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:1135
  391. ... (the last 9 lines are repeated 1 more time)
  392. [34] typeinf_nocycle(::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:1191
  393. [35] typeinf(::Core.Compiler.InferenceState) at ./compiler/typeinfer.jl:14
  394. [36] typeinf_edge(::Method, ::Any, ::Core.SimpleVector, ::Core.Compiler.InferenceState) at ./compiler/typeinfer.jl:497
  395. [37] abstract_call_method(::Method, ::Any, ::Core.SimpleVector, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:345
  396. [38] abstract_call_gf_by_type(::Any, ::Array{Any,1}, ::Any, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:85
  397. [39] abstract_call(::Any, ::Tuple{}, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:776
  398. [40] abstract_apply(::Any, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:519
  399. [41] abstract_call(::Any, ::Array{Any,1}, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:567
  400. [42] abstract_eval_call(::Array{Any,1}, ::Array{Any,1}, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:805
  401. [43] abstract_eval(::Any, ::Array{Any,1}, ::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:890
  402. [44] typeinf_local(::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:1135
  403. [45] typeinf_nocycle(::Core.Compiler.InferenceState) at ./compiler/abstractinterpretation.jl:1191
  404. [46] typeinf(::Core.Compiler.InferenceState) at ./compiler/typeinfer.jl:14
  405. [47] typeinf at ./compiler/typeinfer.jl:10 [inlined]
  406. [48] typeinf_type(::Method, ::Any, ::Core.SimpleVector, ::Core.Compiler.Params) at ./compiler/typeinfer.jl:604
  407. [49] return_type(::Any, ::Any, ::UInt64) at ./compiler/typeinfer.jl:652
  408. [50] return_type(::Any, ::Any) at ./compiler/typeinfer.jl:637
  409. [51] combine_eltypes(::Function, ::Tuple{Array{Float64,1}}) at ./broadcast.jl:627
  410. [52] copy(::Base.Broadcast.Broadcasted{Style,Axes,F,Args} where Args<:Tuple where F where Axes) at ./broadcast.jl:770
  411. [53] materialize(::Base.Broadcast.Broadcasted) at ./broadcast.jl:753
  412. [54] #conditional_nll_ext#88(::Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}}, ::Function, ::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},2},1}}}) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:60
  413. [55] conditional_nll_ext at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:47 [inlined]
  414. [56] #_mean#136(::Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}}, ::Function, ::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, 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Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},2},1}}}, ::Int64) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:343
  415. [57] _mean at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:343 [inlined]
  416. [58] #131 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:314 [inlined]
  417. [59] vector_mode_dual_eval at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/apiutils.jl:35 [inlined]
  418. [60] vector_mode_gradient!(::DiffResults.MutableDiffResult{1,ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, 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Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},2},1}}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/gradient.jl:102
  419. [61] gradient! at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/gradient.jl:35 [inlined]
  420. [62] InnerGradientForHess at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:50 [inlined]
  421. [63] vector_mode_dual_eval(::ForwardDiff.InnerGradientForHess{DiffResults.MutableDiffResult{2,ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2}}},ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, 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  422. [64] vector_mode_jacobian!(::Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2}, ::ForwardDiff.InnerGradientForHess{DiffResults.MutableDiffResult{2,ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2}}},ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, 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  423. [65] jacobian!(::Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2}, ::ForwardDiff.InnerGradientForHess{DiffResults.MutableDiffResult{2,ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2}}},ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, 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Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},1}}}, ::Val{false}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/jacobian.jl:74
  424. [66] hessian!(::DiffResults.MutableDiffResult{2,ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2}}}, ::Function, ::Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}, ::ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},2},1},Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},1}}}, ::Val{true}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:67
  425. [67] hessian!(::DiffResults.MutableDiffResult{2,ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2}}}, ::Function, ::Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}, ::ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},2},1},Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(PuMaS, Symbol("##131#132")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},typeof(PuMaS._mean),PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}},Val{:η},Tuple{Int64}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},2},1}}}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:65 (repeats 2 times)
  426. [68] macro expansion at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:332 [inlined]
  427. [69] #ll_derivatives#134(::Bool, ::Bool, ::Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}}, ::typeof(ll_derivatives), ::typeof(PuMaS._mean), ::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}}, ::Val{:η}, ::Int64) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:326
  428. [70] ll_derivatives(::Function, ::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}}, ::Val{:η}, ::Int64) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:326
  429. [71] #ll_derivatives#133(::Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}}, ::Function, ::Function, ::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::NamedTuple{(:η,),Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}}, ::Symbol, ::Int64) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:319
  430. [72] ll_derivatives at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:319 [inlined]
  431. [73] (::getfield(PuMaS, Symbol("##140#141")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},NamedTuple{(:dv,),Tuple{Array{Normal{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},1}}},Tuple{}})(::Int64) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:360
  432. [74] _mapreduce(::getfield(PuMaS, Symbol("##140#141")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},NamedTuple{(:dv,),Tuple{Array{Normal{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}},1}}},Tuple{}}, ::typeof(Base.add_sum), ::IndexLinear, ::UnitRange{Int64}) at ./reduce.jl:313
  433. [75] _mapreduce_dim(::Function, ::Function, ::NamedTuple{(),Tuple{}}, ::UnitRange{Int64}, ::Colon) at ./reducedim.jl:308
  434. [76] #FIM#139 at ./reducedim.jl:304 [inlined]
  435. [77] FIM at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:357 [inlined]
  436. [78] #marginal_nll#115(::Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}}, ::Function, ::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}, ::PuMaS.FOCEI) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:239
  437. [79] marginal_nll at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:237 [inlined]
  438. [80] #marginal_nll#121(::Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}}, ::Function, ::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::PuMaS.FOCEI) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:280
  439. [81] marginal_nll at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:279 [inlined]
  440. [82] #123 at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:284 [inlined]
  441. [83] _mapreduce(::getfield(PuMaS, Symbol("##123#124")){Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))},Tuple{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}},PuMaS.FOCEI}}, ::typeof(Base.add_sum), ::IndexLinear, ::Array{Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}},1}) at ./reduce.jl:313
  442. [84] #marginal_nll#122 at ./reducedim.jl:308 [inlined]
  443. [85] marginal_nll(::PKPDModel{ParamSet{NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64},RealDomain{Float64}}}},getfield(Main, Symbol("##9#15")),getfield(Main, Symbol("##10#16")),getfield(Main, Symbol("##11#17")),OneCompartmentModel,getfield(Main, Symbol("##12#18"))}, ::Population{Subject{Array{PuMaS.Observation{Float64,NamedTuple{(:dv,),Tuple{Float64}}},1},NamedTuple{(:time, :SEX, :WT),Tuple{Array{Float64,1},Int64,Float64}},Array{PuMaS.Event,1}}}, ::NamedTuple{(:θ₁, :θ₂, :θ₃, :θ₄, :Ω, :σ_add, :σ_prop),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},PDiagMat{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8}}}, ::PuMaS.FOCEI) at /Users/andreasnoack/.julia/dev/PuMaS/src/models/likelihoods.jl:284
  444. [86] (::getfield(Main, Symbol("##23#24")))(::Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}) at ./none:1
  445. [87] vector_mode_gradient(::getfield(Main, Symbol("##23#24")), ::Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}, ::ForwardDiff.GradientConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1}}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/apiutils.jl:35
  446. [88] gradient at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/gradient.jl:17 [inlined]
  447. [89] #94 at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:16 [inlined]
  448. [90] vector_mode_dual_eval(::getfield(ForwardDiff, Symbol("##94#95")){getfield(Main, Symbol("##23#24")),ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}}}, ::Array{Float64,1}, ::ForwardDiff.JacobianConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/apiutils.jl:35
  449. [91] vector_mode_jacobian(::getfield(ForwardDiff, Symbol("##94#95")){getfield(Main, Symbol("##23#24")),ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}}}, ::Array{Float64,1}, ::ForwardDiff.JacobianConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/jacobian.jl:139
  450. [92] jacobian(::Function, ::Array{Float64,1}, ::ForwardDiff.JacobianConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}}, ::Val{false}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/jacobian.jl:17
  451. [93] hessian(::Function, ::Array{Float64,1}, ::ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}}, ::Val{true}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:17
  452. [94] hessian(::Function, ::Array{Float64,1}, ::ForwardDiff.HessianConfig{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},8},1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Main, Symbol("##23#24")),Float64},Float64,8},1}}) at /Users/andreasnoack/.julia/packages/ForwardDiff/okZnq/src/hessian.jl:15 (repeats 2 times)
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