import sys
from PyQt5 import uic
from PyQt5.QtWidgets import QApplication, QWidget, QMainWindow


class MyWidget(QMainWindow):
    def __init__(self):
        super().__init__()
        uic.loadUi('design1.ui', self)

        self.buttonGroup.buttonClicked.connect(self.run)
    def run(self):
        pass

app = QApplication(sys.argv)
ex = MyWidget()
ex.show()
sys.exit(app.exec_())