$ hyperfine "vpython3 ~/depot_tools/autoninja.py -help" "python3 ~/depot_tools/autoninja.py -help"
Benchmark 1: vpython3 ~/depot_tools/autoninja.py -help
Error: Command terminated with non-zero exit code: 1. Use the '-i'/'--ignore-failure' option if you want to ignore this. Alternatively, use the '--show-output' option to debug what went wrong.
tikuta@tikuta1:~/chromium/src$ hyperfine -i "vpython3 ~/depot_tools/autoninja.py -help" "python3 ~/depot_tools/autoninja.py -help"
Benchmark 1: vpython3 ~/depot_tools/autoninja.py -help
  Time (mean ± σ):     240.0 ms ±   5.0 ms    [User: 236.1 ms, System: 109.5 ms]
  Range (min … max):   235.7 ms … 254.7 ms    12 runs

  Warning: Ignoring non-zero exit code.

Benchmark 2: python3 ~/depot_tools/autoninja.py -help
  Time (mean ± σ):      99.1 ms ±   0.9 ms    [User: 73.6 ms, System: 25.5 ms]
  Range (min … max):    97.1 ms … 101.0 ms    29 runs

  Warning: Ignoring non-zero exit code.

Summary
  python3 ~/depot_tools/autoninja.py -help ran
    2.42 ± 0.05 times faster than vpython3 ~/depot_tools/autoninja.py -help