Powder Domperidone CAS 57808-66-9 /For management of dyspeps

Powder Domperidone CAS 57808-66-9 /For management of dyspepsia/Anti-Emetic

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MOQ:10G

Domperidone Description:
Domperidone belongs to the group of medications called dopamine antagonists. It is used to treat slowed movement in the gastrointestinal tract associated with diabetes and gastritis (inflammation of the stomach lining). For these people, domperidone improves symptoms of nausea, vomiting, bloating, and feeling of fullness.

Domperidone is also used to prevent stomach problems such as nausea and vomiting associated with certain medications used to treat Parkinson's disease. It works to improve symptoms by helping the stomach to empty more quickly and to reduce nausea.

Product Name: Domperidone
Synonyms:  2h-benzimidazol-2-one,1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzi;5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidaz;kw-5338;midazol-1-yl)propyl)-4-piperidinyl)-;DOMPERIDONE;4-(5-chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine;ALPHA-[2-(DIISOPROPYLAMINO)ETHYL]-ALPHA-PHENYL-2-PYRIDINE-ACETAMIDE;5-CHLORO-1-[1-[3-(2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOL-1-YL)PROPYL]-4-PIPERIDINYL]-1,3-DIHYDRO-2H-BENZ-IMIDAZOL-2-ONE
CAS:    57808-66-9
MF:    C22H24ClN5O2
MW:    425.91
EINECS:    260-968-7

Chemical Properties: white powder
Usage: COX2 inhibitor, antiinflammatory, antiarthritic
Usage: A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
Usage: For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
Biological Activity: Peripheral dopamine D 2 -like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED 50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).


Use of domperidone:

Increased rate of gastric emptying
The active ingredient in Domperidone is domperidone. Domperidone works by tightening the muscles at the entry to the stomach and relaxing the muscles at the exit of the stomach. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness.

Control of the vomiting reflex
Domperidone also blocks or reduces stimulation in an area of the brain known as the vomiting centre by suppressing nerve messages from the gut or preventing them from being sent. This reduces the sensation of nausea and prevents vomiting.

Domperidone is available in tablet, suspension and suppository form. Domperidone tablets only take 15 to 30 minutes to take effect and their effect will wear off after six to eight hours. Domperidone suppositories provide relief in just one to two hours.

How to use Domperidone?

For nausea, one Domperidone tablet should be taken orally and swallowed whole with some water, preferably before meals. For migraine, one tablet should be taken as soon as you feel an attack coming on. If you are vomiting, we recommend using Domperidone suppositories.

Before taking domperidone:

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking domperidone it is important that your doctor knows:

If you are pregnant, trying for a baby or breast-feeding.
If you have problems with your liver or kidneys.
If you have problems with your heart or if you have been told you have an irregular heart rhythm.
If you know you have any problems with your digestive system, such as a blockage or any internal bleeding.
If you have a tumour on your pituitary gland known as a prolactinoma.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
If you have ever had an allergic reaction to any medicine.