from win32com.client import Dispatch, VARIANT
from pythoncom import VT_VARIANT
import collections


appObj = Dispatch("Illustrator.Application")
docObj = appObj.Documents.Add()

def variant(data):
    return VARIANT(VT_VARIANT, data)

def vararr(*data):
    if (  len(data) == 1 and
          isinstance(data, collections.Iterable) ):
        data = data[0]
    return map(variant, data)

pathItem = docObj.PathItems.Add()
pathItem.SetEntirePath( vararr( [0.0,0.0], [20.0,20.0] )  )

#or you can have a iterable of iterables
pathItem = docObj.PathItems.Add()
pathItem.SetEntirePath( vararr( [[30.0,10.0], [60.0,60.0]] )  )