from tkinter import *

root = Tk()

lbl_question = Label(root, text="Do you want to continue?").grid(row=0, column=0, columnspan=2, sticky=W+E)
btn_yes = Button(root, text="Yes").grid(row=1, column=0, sticky=E)
btn_no = Button(root, text="No").grid(row=1, column=1, sticky=W)

root.mainloop()