import pandas as pd

df = pd.DataFrame({
    'From': ['Moscow', 'Moscow', 'St. Petersburg', 'St. Petersburg', 'St. Petersburg'],
    'To': ['Rome', 'Rome', 'Rome', 'Barcelona', 'Barcelona'],
    'Is_Direct': [False, True, False, False, True],
		'Has_luggage': [True, False, False, True, False],
		'Price': [21032, 19250, 19301, 20168, 31425],
		'Date_From': ['01.07.19', '01.07.19', '04.07.2019', '03.07.2019', '05.07.2019'],
		'Date_To': ['07.07.19', '07.07.19', '10.07.2019', '09.07.2019', '11.07.2019'],
		'Airline': ['Belavia', 'S7', 'Finnair', 'Swiss', 'Rossiya'],
		'Travel_time_from': [995, 230, 605, 365, 255],
		'Travel_time_to': [350, 225, 720, 355, 250],
})
print(df[(df['Is_Direct'] == True) & (df['Date_To'] ~ isin(('09.07.2019', '10.07.2019', '11.07.2019')))]) # впишите нужное условие