How to properly cast objects created through reflection

loop through assemblies
  loop through types in assembly
    // Filter out unwanted types
    if (!type.IsClass || type.IsNotPublic || type.IsAbstract )
      continue;
    // This successfully created the right object
    object o = Activator.CreateInstance(type);
    // This threw an Invalid Cast Exception or returned null for an "as" cast
    // even though the object implemented IPlugin
    IPlugin i = (IPlugin) o;

using System.Runtime.Remoting;
ObjectHandle oh = Activator.CreateInstance(assembly.FullName, type.FullName);
// This worked as I intended
IPlugin i = (IPlugin) oh.Unwrap();
i.DoStuff();

IPluginModule pluginModule = (IPluginModule)Activator.CreateInstance(curType);

Activator.CreateInstance(type, true);