sample = D1.merge(D2,left_on=[ 'A' or'B' or'C'or 'D' or E],
right_on=['A'], how='left')

sample = pd.concat([D1.merge(D2,left_on='A', right_on= 'A', how='left'),
D1.merge(D2,left_on='B', right_on='A', how='left'), D1.merge(D2,
left_on='C',right_on='A', how='left'),D1.merge(D2,left_on='D',
right_on='A', how='left'),D1.merge(D2,left_on='E', right_on='A',
how='left')])

dupes = (sample['A'] == sample['B']) == (sample['C'] == sample['D']) ==
sample['E']
sample=sample.loc[~dupes]



ValueError: The truth value of a Series is ambiguous. Use a.empty,
 a.bool(), a.item(), a.any() or a.all().