\documentclass{standalone}
\usepackage{times}
\usepackage{tikz}

\begin{document}
		\begin{tikzpicture}[scale=2]
		%\fontfamily{times}
		\tikzstyle{rect}=[rectangle,draw=black!75,fill=black!20,minimum size=0mm, node distance=7.5pt]
		\tikzstyle{circ}=[circle,thick,draw=black!75,fill=blue!30,minimum size=0mm, node distance=80pt]

		\tikzstyle{blank}=[rectangle,minimum size=5pt, node distance=6pt]
		\tikzstyle{gray circ}=[circ,draw=black!75,fill=black!20]
		\tikzstyle{red circ}=[circ,draw=red!75,fill=red!20]
		\tikzstyle{red corrupt}=[circ,draw=black!75,fill=red!40]
		\tikzstyle{purple circ}=[rect,draw=black!75,fill=green!40!red!40,minimum size=10pt]
		\tikzstyle{scoring}=[circ,draw=blue!5!,fill=red!20]
		\tikzstyle{every label}=[black]
		\tikzstyle{green rect}=[rect,draw=black!75,fill=green!20]
		\tikzstyle{red rect}=[rect,draw=black!75,fill=red!20]

		\tikzstyle{red}    = [fill=red!20]
		\tikzstyle{blue}   = [fill=blue!20]
		\tikzstyle{yellow} = [fill=yellow!30]
		\tikzstyle{green}  = [fill=green!20]
		\tikzstyle{teal}   = [fill=red!0!green!30!blue!30]
		\tikzstyle{laven}  = [fill=red!30!green!30!blue!40!]
		\tikzstyle{purple} = [fill=green!40!red!40]
		\tikzstyle{gray}   = [draw=black!75,fill=black!20]
		\tikzstyle{redd}   = [draw=red!60]

		\begin{scope}
		\node [circ, blue, double] (p) {\textbf{P}};
		\node [circ, green, double, xshift=-50pt] (d) [below of=p]{\textbf{D}};
		\node [circ, purple, double, xshift=50pt] (g) [below of=p]{\textbf{P}};
		\node [circ, red, double, xshift=-20pt] (s) [below of=d]{\textbf{\scriptsize SE}};

		\node [circ, laven, double, xshift=50pt] (b) [below of=d]{\textbf{D}};

		\node [circ, gray, double, xshift=20pt] (n) [below of=g]{\textbf{\scriptsize AB}};

		\node [circ, teal, double, xshift=-5pt, yshift=-45pt] (m) [right of=g]{\textbf{M}};

		\node [circ, yellow, double, xshift=5pt, yshift=-5pt] (ec1) [right of=g]{\scriptsize\textbf{GO}};

		\node [circ, yellow, double, xshift=-15pt, yshift=45pt] (ip) [right of=g]{\bf \scriptsize IP};

		\node [circ, yellow, double, xshift=5pt, yshift=-15pt] (atc1) [left of=d]{\textbf{A}};

		\node [circ, yellow, double, xshift=25pt, yshift=40pt] (dg) [left of=d]{\textbf{C}};

		% ------------------------------------------------------------
		\draw[bend left=10, <->] (d) to node [anchor=south, yshift=-14pt] {\scriptsize Drug Target Protein} (g);

		\draw[bend left=10, <->] (d) to node [anchor=east, xshift=15pt, yshift=5pt] {\scriptsize \rotatebox[origin=c]{55}{Drug Pathway}} (p);
		\draw[bend left=10, <->] (s) to node [anchor=east, xshift=2pt, yshift=0pt] {\scriptsize \rotatebox[origin=c]{75}{Drug Side-effect}} (d);
		\draw[bend left=10, <->] (b) to node [anchor=east, xshift=8pt, yshift=-2pt] {\scriptsize \rotatebox[origin=c]{60}{Protein Disease}} (g);
		\draw[bend left=10, <->] (d) to node [anchor=south, xshift=4pt, yshift=-18pt] {\scriptsize \rotatebox[origin=c]{305}{Drug Disease}} (b);
		\draw[bend left=10, <->] (g) to node [anchor=east, xshift=15pt, yshift=5pt] {\scriptsize \rotatebox[origin=c]{40}{Protein InterPro}} (ip);
		\draw[bend right=10, <->] (g) to node [anchor=west, xshift=-10pt, yshift=5pt] {\scriptsize \rotatebox[origin=c]{305}{Protein Pathway}} (p);
		\draw[bend right=10, <->] (m) to node [anchor=west, xshift=-17pt, yshift=-10pt] {\scriptsize \rotatebox[origin=c]{320}{Protein Motif}} (g);
		\draw[bend right=10, <->] (n) to node [anchor=west, xshift=-20pt, yshift=-5pt] {\scriptsize \rotatebox[origin=c]{285}{Protein Antibody}} (g);
		\draw[bend left=10, <->] (g) to node [anchor=south, xshift=5pt] {\scriptsize Protein GO} (ec1);

		\draw[bend right=10, <->] (d) to node [anchor=south east, xshift=10pt, yshift=3pt] {\scriptsize ATC Class} (atc1);

		\draw[bend right=10, <->] (d) to node [anchor=south east, xshift=20pt, yshift=-10pt] {\scriptsize \rotatebox[origin=c]{320}{Drug Class}} (dg);

		\end{scope}

		\end{tikzpicture}
\end{document}