The effects of lysergic acid amide

⬇️ 𝚀𝚞𝚘𝚝𝚎𝚜 ⬇️

D-lysergic acid amide (designation of compound undergoing tests: LA 111) was tested pharmacologically and clinically during the course of investigations on d-lysergic acid diethylamide (LSD 25) and related compounds long before it was known to be a component of ololiuhqui. Already at that stage we had, in experiments on ourselves, ascertained a psychotomimetic activity with a marked narcotic component with dosages of 0.5 to 1 mg. (Hofmann 1963)

 

Parallels between the three studies wherein synthetic LAA was administered:

| Hofmann 1963 | Heim 1968 | Solms 1956 |
|---|---|---|
| | "dysphoria" | "irritative depressive moods" |
| "incapable of clear thoughts" | "impairment of concentration"　｜　"clouding of consciousness" | "impaired concentration"　｜　"clouding of consciousness"　｜　"With middle to strong doses in 1 subject work became increasingly difficult after 30 minutes" |
| "Desire to lie down and sleep. Genuine physical and mental tiredness, which is not experienced as an unpleasant sensation. Slept for 3 hours." | "test subject SB [...] had to go to bed after an antineoplastic injection and did not recover until the following day."　｜　"In the fourth and fifth study periods, however, they appeared to be sufferingly exhausted and even sleepy and dazed." [isoergine] | "and an immediate desire to sleep, after which he slept for three hours during the day". |
| "a feeling of mental emptiness and of the unreality and complete meaninglessness of the outside world". [isoergine] | "In the test subject PS (5 mg), severe nausea with a drop in blood pressure suddenly occurred after 3½ hours, which was controlled with analeptics and antinausea after about 30 minutes. At the same time, the test subject experienced a feeling of total annihilation and fear of death, which subsided after vomiting about 60 minutes later, but only completely subsided during the course of the night." [isoergine]　｜　"In the fourth and fifth study cross-sections, they complained of difficulty in thinking and a lack of ideas." [isoergine] | "Indifference"　｜　"a feeling of sinking into nothing" |

[Hofmann, Albert. 1963-11-22. The Active Principles of the Seeds of Rivea corymbosa and Ipomoea violacea [sic✱]. Cambridge, MA: Botanical Museum, Harvard University. 10.5962/p.168542](https://archive.org/details/mobot31753003541080/). Pharmacological and clinical activity of the isolated alkaloids

[Heim, E., Heimann, H., Lukács, G. 1968. Die psychische Wirkung der mexikanischen Droge „Ololiuqui“ am Menschen. Psychopharmacologia, 13 (1): 35–48](https://open-slum.org). 10.1007/BF00401617. ISSN 0033-3158

Solms, H. 1956. Relationships between chemical structure and psychoses with the use of psychotoxic substances; comparative pharmacopsychiatric analysis: a new research method. Journal of Clinical and Experimental Psychopathology, 17 (4): 429–433. PMID 13406032](https://upload.erowid.org/references/refs_view.php?ID=4195&S=harm)

 

✱"This study addresses the longstanding taxonomic confusion between two plant species within the Convolvulaceae family: Ipomoea tricolor Cav. and Ipomoea violacea L., historically mistaken as synonymous." [Greco, E., Farci, A., Florian, F., Pallavicini, A., Miani, A., Barbieri, P., Samorini, G. 2025. Analytical identification of ergot alkaloids in Ipomoea species: Resolving historical, forensic, and legal ambiguities. Forensic Chemistry, 45. 10.1016/j.forc.2025.100686](https://www.sciencedirect.com/science/article/abs/pii/S2468170925000487)