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- Antibacterial / treatment of amebiasis, trichomoniasis and anaerobic bacteria infection/Metronidazole CAS: 443-48-1
- Email:kathelin@yccreate.com
- Skype:live:kathelin_4
- WhatsApp:+86-188 7222 0706
- Metronidazole
- Synonyms:1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole;1H-Imidazole-1-ethanol, 2-methyl-5-nitro-;1H-Imidazole-1-ethanol,2-methyl-5-nitro-;1-Hydroxyethyl-2-methyl-5-nitroimidazole;2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethanol
- CAS:443-48-1
- MF:C6H9N3O3
- MW:171.15
- EINECS:207-136-1
- Product Categories:Active Pharmaceutical Ingredients;API's;Peptide Synthesis/Antibiotics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;FLAGYL;antibiotic
- Chemical Properties:white to slightly yellow crystalline powder
- Assay:99%
- Usage:Used as an antibacterial in the treatment of rosacea. Antiprotozoal (trichomonas). A potential human carcinogen.
- Air & Water Reactions:Insoluble in water.
- Reactivity Profile:Metronidazole darkens on exposure to light. Metronidazole is incompatible with strong oxidizing agents.
- Fire Hazard:Flash point data for Metronidazole are not available; however, Metronidazole is probably combustible.
- Chemical property
- White or milky white crystalline powder. Melting point is 158-160. Soluble in hot water, slightly soluble in ethanol, slightly soluble in water or chloroform, slightly soluble in ether. Bitter and slightly salty.
- Uses 1.In 1959, the goods were used for the treatment of vaginal trichomoniasis. Since 1970, it has used for the intestine, extraintestinal amebiasis, and it has high efficacy, low toxicity, wide application. it has mutagenic and teratogenic effects on experimental animals.
- 2.It has strong antibacterial effect on most anaerobic bacteria.
- 3.It is used for the treatment of amebiasis, trichomoniasis and anaerobic bacteria infection.
- Methods of production It is synthetized by 2-methyl-5-nitro imidazole (see 25010) and ethylene oxide addition. 2-methyl-5-nitro imidazole dissolved in formic acid and at 30-40℃ successive adding epoxy ethane, and sulfuric acid in the middle of adding feeding. and reaction for 1 h, after that. Decompression to recycle formic acid, water solution is cooled to 10 ℃, filter. The filtrate with sodium hydroxide solution to adjust pH = 10. Set aside to cool, filtering, washing to nearly alterations into neutral, recrystallization in water. Activated carbon decolorization to get metronidazole.
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