from ipywidgets import Image
from IPython.display import display, Javascript
im = Image(value=open(filename, 'rb').read())
im.add_class('the_image_class')

def on_image_click():
    #do something....
    return

#Now, I wrote some javascript(jQuery) code like this...
js = ''' $(".the_image_class").on("click", function(e){
             var kernel = IPython.notebook.kernel;
             kernel.execute("on_image_click()");
          });'''

#then, run the javascript...
display(Javascript(js))

%%javascript
let kernel = IPython.notebook.kernel;
kernel.execute("on_image_click()");

%%javascript
let callback = {
        iopub: {
            // have a look at data on console for its structure
            output: (data) => {console.log(data)}}
        }
};
let kernel = IPython.notebook.kernel;
kernel.execute("on_image_click()", callback);