$newWeb = New-Object Microsoft.SharePoint.Client.WebCreationInformation
$newWeb.Url = 'someURL'
$newWeb.UseSamePermissionsAsParentSite = $false
$newWeb.Title = 'Some Web'
$newWeb.WebTemplate = "STS#0"
$spWeb = $ctx.Web.Webs.Add($newWeb)
$ctx.Load($spWeb)
$ctx.ExecuteQuery()

function Set-SPOListBreakRoleInheritance
{

   param (
        [Parameter(Mandatory=$true,Position=1)]
        [string]$Username,
        [Parameter(Mandatory=$true,Position=2)]
        [string]$Url,
        [Parameter(Mandatory=$true,Position=3)]
        [string]$AdminPassword,
        [Parameter(Mandatory=$false,Position=4)]
        [bool]$IncludeSubsites=$false
        )



   $password = ConvertTo-SecureString -string $AdminPassword -AsPlainText -Force
  $ctx=New-Object Microsoft.SharePoint.Client.ClientContext($Url)
  $ctx.Credentials = New-Object Microsoft.SharePoint.Client.SharePointOnlineCredentials($Username, $password)
  $ctx.Load($ctx.Web.Lists)
  $ctx.Load($ctx.Web)
  $ctx.Load($ctx.Web.Webs)
  $ctx.ExecuteQuery()
  Write-Host
  Write-Host $ctx.Url -BackgroundColor White -ForegroundColor DarkGreen
  foreach( $ll in $ctx.Web.Lists)
  {

        $ll.BreakRoleInheritance($true, $false)
    $ll.Update()

        try
        {
        $ctx.ExecuteQuery()
        Write-Host "Removed inherited permissions for " $ll.Title
        }
        catch
        {
        Write-Host "Failed to remove permissions for " $ll.Title
        }



        }









  if($ctx.Web.Webs.Count -gt 0 -and $IncludeSubsites)
  {
    for($i=0; $i -lt $ctx.Web.Webs.Count ; $i++)
    {
        Set-SPOListBreakRoleInheritance -Url ($ctx.Web.Webs[$i].Url) -Username $Username -AdminPassword $AdminPassword -IncludeSubsites $IncludeSubsites
    }

  }


  }


# Paths to SDK. Please verify location on your computer.
Add-Type -Path "c:Program FilesCommon Filesmicrosoft sharedWeb Server Extensions15ISAPIMicrosoft.SharePoint.Client.dll"
Add-Type -Path "c:Program FilesCommon Filesmicrosoft sharedWeb Server Extensions15ISAPIMicrosoft.SharePoint.Client.Runtime.dll"



Set-SPOListBreakRoleInheritance -Username "trial@trialtrial123.onmicrosoft.com" -Url "https://trialtrial123.sharepoint.com" -AdminPassword "Pass" -IncludeSubsites $false

[System.Reflection.Assembly]::LoadWithPartialName("Microsoft.SharePoint.Client")
[System.Reflection.Assembly]::LoadWithPartialName("Microsoft.SharePoint.Client.Runtime")


Function Get-ClientContext([string]$Url,[string]$UserName,[string]$Password)
{
    $SecurePassword = $Password | ConvertTo-SecureString -AsPlainText -Force
    $context = New-Object Microsoft.SharePoint.Client.ClientContext($Url)
    $context.Credentials = New-Object Microsoft.SharePoint.Client.SharePointOnlineCredentials($UserName, $SecurePassword)
    return $context
}



Function Web-BreakInheritance([Microsoft.SharePoint.Client.Web]$Web)
{
     $Web.BreakRoleInheritance($true, $false)
     $Web.Context.ExecuteQuery()
}

$UserName = "jdoe@contoso.onmicrosoft.com"
$Password = Read-Host -Prompt "Enter the password"
$Url = "https://contoso.sharepoint.com/blog"

$context = Get-ClientContext -Url $Url -UserName $UserName -Password $Password
Web-BreakInheritance -Web $context.Web
$context.Dispose()