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server {
    listen       80;
    //中略

    location /hoge {
        include uwsgi_params;
        uwsgi_pass unix:/var/run/uwsgi/app/app.sock;
    }

[uwsgi]
uid = nginx
gid = nginx
socket = /var/run/uwsgi/app/app.sock
chmod-socket = 777
chdir = /var/www/中略/hoge/
callable = application
wsgi-file = /var/www/中略/hoge/hoge.py

def application(environ, start_response):
    start_response('200 OK', [('Content-type', 'text/html')])
    return "<html><head><title>Test</title></head><body><div>Hello</div></body></hetml>"

$ uwsgi --ini hoge.ini

[uWSGI] getting INI configuration from uwsgi.ini
*** Starting uWSGI 2.0.17 (64bit) ***
//中略
current working directory: /var/www/中略/hoge
detected binary path: /usr/bin/uwsgi
!!! no internal routing support, rebuild with pcre support !!!
chdir() to /var/www/中略/hoge/
*** WARNING: you are running uWSGI without its master process manager ***
//中略
lock engine: pthread robust mutexes
thunder lock: disabled (you can enable it with --thunder-lock)
uwsgi socket 0 bound to UNIX address /var/run/uwsgi/app/app.sock fd 3
Python version: 3.6.4
*** Python threads support is disabled. You can enable it with --enable-threads ***
//中略
*** Operational MODE: single process ***
WSGI app 0 (mountpoint='') ready in 0 seconds on interpreter 0xe8e200 pid: 27939 (default app)
*** uWSGI is running in multiple interpreter mode ***
spawned uWSGI worker 1 (and the only) (pid: 27939, cores: 1)
[pid: 27939|app: 0|req: 1/1] IPアドレス () {44 vars in 883 bytes} [日時] GET /hoge/hoge.py => generated 0 bytes in 0 msecs (HTTP/1.1 200) 1 headers in 44 bytes (75 switches on core 0)
[pid: 27939|app: 0|req: 2/2] IPアドレス () {44 vars in 883 bytes} [日時] GET /hoge/hoge.py => generated 0 bytes in 0 msecs (HTTP/1.1 200) 1 headers in 44 bytes (75 switches on core 0)

return b'<html><body>Hello, world</body></html>'