Thymosin α1 Acetate 10Mg/Vial

Peptide Raw Powder Thymosin α1 Acetate To Enhance Cell-Mediated Immunity Cas No.:62304-98-7


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Thymosin α1 Acetate description
Thymosin Alpha-1 is a component of Thymosin Fraction 5 responsible for restoring immune function in animals lacking thymus glands. It was the original peptide synthesized from the Thymosin Fraction 5. Unlike β Thymosins, which are genetically and chemically unrelated, Thymosin α 1 is produced as a 28-amino acid peptide fragment from a longer, 113-amino acid precursor, prothymosin alpha. Research has shown it to enhance cell-mediated immunity in experimental animals and research subjects.

Thymosin Alpha-1 is being researched for the treatment of Hepatitis B and C, and it is also approved for inclusion with vaccines to boost the immune response in the treatment of other diseases.
Exhibiting a variety of immune regulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.

Thymosin α1 Acetate Spec.
Product Name:Thymosin α1 Acetate
Synonyms: Thymosin α1 Acetate;Thymosin α 1 Acetate(Thymalfasin);Thymosina1Acetate;thymosin α1 bovine;Thymosinα1 bovine,Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn;ThyMosins alpha 1;Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH acetate salt;Thymosin α1, Thymalfasin
Properties
Sequence:Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-
Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-
Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Cas No.:62304-98-7
Molecular Formula:C129H215N33O55
Molecular Weight:3108.3
Purity (HPLC):98.0%min
Appearance:White powder
Single Impurity (HPLC):1.0%max
Amino Acid Composition:±10% of theoretical
Peptide Content (N%):≥80.0%
Water Content(Karl Fischer):≤5.0%
Specific Rotation (20/D):-95.0~-105.0°(c=0.5 1%HAc)
Acetate Content (HPIC):≤15.0%
MS(ESI):Consistent
Mass Balance:	95.0~105.0%
storage temp.  −20°C

Abstract

Thymosin Alpha-1 is a component of Thymosin Fraction 5 responsible for restoring immune function in animals lacking thymus glands. It was the original peptide synthesized from the Thymosin Fraction 5. Unlike β Thymosins, which are genetically and chemically unrelated, Thymosin α 1 is produced as a 28-amino acid peptide fragment from a longer, 113-amino acid precursor, prothymosin alpha. Research has shown it to enhance cell-mediated immunity in experimental animals and research subjects...

Thymosin Alpha-1 is being researched for the treatment of Hepatitis B and C, and it is also approved for inclusion with vaccines to boost the immune response in the treatment of other diseases.

Exhibiting a variety of immune regulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.


Application

Thymosin alpha-1 is now approved in developed or developing countries for the treatment of hepatitis B and C, and is also used to enhance the immune response in the treatment of other diseases.

Demonstrating various immunomodulatory properties, thymosin-alpha-1-induced murine T cell precursors and human thymocyte differentiation and functional immature umbilical cord blood lymphocyte terminal differentiation and induction of IL-2, high affinity IL-2 Receptor production, and peripheral blood mononuclear cells B cell growth factor. T helper cells and cytotoxicity / inhibition of T cell populations are targets of thymosin activity.

It has been shown that thymosin-alpha-1 increases the efficiency of macrophage antigen presentation and is an endogenous modulator of alpha-thrombin activity.

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