Articaine hydrochloride

Product Description

Product Name:Articaine hydrochloride
CAS: 23964-57-0
MF: C13H20N2O3S.ClH
MW: 320.839
EINECS: 245-957-7
Appearance: White crystalline powder

Description


articaine is a dental local anesthetic. it is the most widely used local anesthetic in a number of european countries[2] and is available in many countries around the world



articaine hydrochloride,articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. it is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia.

articaine hydrochloride, in comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.



Applications

Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor .
The combination of articaine can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.
 articaine hydrochloride, articaine blocks nerve conduction by reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. the blocking action of articaine on the sodium channel is state dependent: it has the highest affinity for the open state, an intermediate affinity for the inactivated state, and the lowest affinity for the resting state.
 articaine hydrochloride, the degree of neuronal block is affected by the diameter of the nerve. larger-diameter fibers (touch/pressure/ motor) require higher concentrations of local anesthetic compared with small myelinated fibers (pain afferents).articaine is lipid soluble, highly protein-bound (94%), and has a dissociation constant (pka) of 7.8. articaine is an intermediate-potency, short-acting local anesthetic with a fast onset of action.

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