>>11302595
You'd be surprised. There's probably a DMT-containing plant on your backyard right now. Please read this until the end before deciding anything tho.

Keeping things simple, if you're Canadian, you can do this over-the-counter. This guy, God bless his heart, risked his ass by being the first one to openly provide psychedelic microdoses, and it's going smoothly so far. This as as close to medical-grade as it gets at the moment, that Spravato bullshit notwithstanding: https://mushroomdispensary.com

Other than that, there are a million other, more complicated ways to get the goods. First, keep in mind only classical psychedelics and ketamine are confirmed to work, and with completely different mechanisms, it seems. Regardless, both types have plenty of anecdotal evidence and personal reports on the internet regarding microdosing, so you don't have to trip at all. Rule of thumb is 1/10 of a recreative dose every 3 days, tweaking that up or down depending on tolerance buildup. The third day is supposed to be a "control day" of sorts on which the microdose taken two days before is completely clear off your body, and it's possible to skip such a thing -- self-medicating is all about weighing risks. Ketamine is hallucinogenic despite not being a psychedelic, so some might be tempted to see the connection between its hallucinogenic effects and its anti-depressant action, but that seems to be a coincidence -- my best guess is that K's hallucinations are indirectly caused by a sensory deprivation of sorts which kicks with the dissociation it causes. (Not all substances which cause hallucinations are psychedelic, by the way, they are just the most famous class.) Also, ketamine's antidepressant effect is remarkably strong and sudden compared even to those of  classical psychedelics, to the point it might be adopted as the first anti-suicide drug one day.

An important note here is that classical psychedelics have the bad habit of cancelling themselves out with serotonin reuptake inhibitors, which are the current dominant class of antidepressant. So if you take those, your shitty antidepressant might keep you from a better antidepressant. How ironic is that? It's not known if classical psychedelics' antidepressant effect still takes place even with this mutual cancellation with SRIs nor if you stay for some time without the effects of the SRIs, but it's a commonly known fact that people on SSRIs have to take higher doses of classical psychedelics, usually about twice their usual dose, in order to get the same trip, which isn't a good sign. So, all things told, if you do take this class of med, ket is probably a better choice.

So then, about choices and acquisitions. Amongst the classical psychedelics, the big ones are DMT, shrooms, mescaline and LSD. Ketamine is the representative of a separate class, dissociatives, much more obscure, and, at any rate, ket is the only one whose antidepressant effect is confirmed and studied. Tho dissociatives can cause hallucinations, they do it through a completely separate mechanism, so the link between hallucinogenic substances and antidepressant effect is most likely a coincidence.

DMT and its close relatives are present in a preposterous amount of plant species across the globe, and it's highly likely that at least a few of them can be legally acquired wherever you live. It's up to you to look this up, obviously. Legit stores selling ayahuasca and analog mixes ("anahuasca") can be easily googled, check normie sites like Reddit for customer reviews. DMT Nexus has long lists of species, but you'll probably be able to safely buy at least a few of the most common plants. DMT-containing plants usually involve extraction, and there are a million methods detailed across the internet. It's possible to just consume the powdered vegetable, but unadvisable, at least in recreative doses, as the nausea that often acompanies DMT plants is almost always a result of that vegetable stuff which the human body can't process (full doses of ayahuasca brews often involve vomiting). For microdoses tho, there's so little material that ingesting crude material is more feasible. Ayahuasca and analogs have an added consideration tho: DMT's recreative effects don't work orally unless combined with beta-carbolines -- ayahuasca and its analogs are mixtures of exactly those things -- and so far, it's not known if the antidepressant effect requires that activation. So a better DMT choice might be Mimosa hostilis/tenuiflora root bark, which contains it all by itself. An interesting sidenote: if you ever intend to microdose without the aforementioned "control day", DMT is your best bet, as it curiously builds up no tolerance.

On that note, shrooms are remarkably straightforward to both farm and consume, as they contain both the psychedelics and the beta-carbolines too, so if it wasn't for the varying concentrations, it would be the perfect choice. (Then again, microdoses are so low that even an accidental double or triple dose is unlikely to cause inconvenience.) They're not as common as DMT plants tho, and are banned in far more places, but if they're okay wherever you live, they're a great choice, especially if there's a reputable, legal seller available there who can provide them with a reliably steady product. These days, they might also have tips about microdosing too.

Mescaline is like a much gentler version of DMT -- it's actually chemically closer to ecstasy, but without that serotonin depletion crap. It's harder to get your hands on tho, as only certain cactii produce it, and they seem to be even harder on the human digestive tract than common plants matter. Full 'in natura' doses of mescaline cactii are almost guaranteed to involve purging. Tho, again, microdoses shouldn't be a problem either way. Also the legality depends a lot on your location.

LSD is banned almost everywhere, but it's so potent it makes for easy and unbelievably cheap microdosing -- assuming the tabs have been properly prepared. So it's better reserved for when its supplier is a well-known and trusted source, as with some darknet vendors.

Ketamine, like LSD, doesn't have natural sources. In fact, the overwhelming supply is legit, pharmaceutical-grade stuff which has been diverted to the black market, which makes K the choice for most precise dosing by far. Ketamine itself is legal virtually everywhere, you see, as it's one of the most basic drugs in modern medicine, a powerful anesthetic. It's the sale which is usually controlled, and recreative use, outright forbidden. So besides the darknet, getting this might just be a matter of paying a bit extra to a vet store employee.

These are just the most simple alternatives. There's enough material to fill books.

I'll end on a few security notes.

I wrote a little text a little while ago on the obscure topic of possible permanent psychological damage without direct, physical harm to brain cells which might be caused by drugs. Taking in consideration I'm relatively educated but still a layman, I divided it into two types: one is purely psychological, which is nothing more than trauma, which can be caused by any unpleasant experience intense enough and can be avoided by knowing how to ride out bad trips; the other is biochemical, and seemingly only happens with unfortunate souls with presumably genetic predisposition towards psychosis-related illnesses, chiefly schizophrenia. https://pastebin.com/pqfcJne2

In that text I also collected a lot of advice regarding use of any drug in the next-to-last paragraph. I'd just like to emphasize this, because they're not specific to antidepressant drug therapy, and are always valuable. Most important, I think, is to always study every single substance thoroughly before taking it, trying a tiny bit at first to avoid a tragedy due to unpredictable allergy and minding any and all substance interactions, which in some cases, might even involve food. This is the case with those beta-carbolines I mentioned. Also,

Ketamine, unless consumed chronically (pretty much any drug has another horrible set of side effects if abused for long), is supposed to have no side effects except for possible bladder damage. The dosage at which this happens is a complete mystery. Microdosing should be safe, but if you do follow this route and notice any urinary tract issues, stop consumption immediately. Chronic users who didn't pay heed have had their entire bladders and even their dicks removed. Some ketamine analog(s) might not have this issue, but even considering only internet trip reports, I don't know of any which is confirmed to be safe by users, and, at any rate, only ket itself is scientifically confirmed to have antidepressant. The only other health concern when it comes to sane usage isn't just ketamine's but happens with all CNS depressants (utterly unrelated to depressive disorder) as they all temporarily decrease the working rate of your autonomic nervous system. The telltale sign is slower and shallower breathing. It's unlikely someone can consume a dose of ketamine high enough to cause respiratory arrest, but the effects of all CNS depressants stack with each other, and that includes some meds and, more importantly, alcohol. So an otherwise safe dose of K can be deadly if, for example, you're drunk.

Classical psychedelics would be harmless, were it not for the aforementioned mysterious biochemical risk. So far, there are no reports of microdoses ever triggering this putative "latent schizophrenia", but consider this your warning. If you intend to not just microdose but also trip balls but have a family and/or personal history of psychosis-related illness, stay away from classical psychedelics at all costs. Drugs which induce hallucinations by different mechanisms, which includes ketamine, seem to be safe, but again, be warned.

You'll find people saying just about every drug helped them with depression, but that's all likely to be just personal comfortation, like some activity or other which has a therapeutic effect on some people who enjoy it. Classical psychedelics and ketamine are the only ones so far proven to have this strong antidepressant effect. Weed can have psychedelic effects, tho it's rare and unlikely, and I explain this in more detail in the Pastebin above. This means that might actually the same antidepressant effect as classical psychedelics -- and the same risk of triggering the "latent eschizophrenia" as well. Maybe you have noticed at some point how weird is it that a drug as otherwise harmless as weed can cause some people to go insane for good and with such a random, unpredictable frequency. I offer a possible theory.

I guess that's it. There's a lot of good information about microdosing nowadays on the internet, Reddit has quite a bit about it, and it's also good for personal reports. There are books too, check Libgen for James Fadiman, Karl Janen and Stephen hyde, who wrote accessible books about self-medicating with K microdoses, and a whole library of stuff on psychedelic therapy in general. Good luck.