Accounts.createUser({
        email: 'example@example.com',
        password: 'testing',
        profile: {
            name: "Jack",
            gender: "Male",
            skypeid: "jack123",
            timezone: {
                name: "UTC",
                offset: "UTC"
            }
        }
    });

let newUser = { ... };
let user = Accounts.createUser(newUser);

Meteor.users.update({ _id: user }, { $set: { "profile.name": "Jake" } });

Meteor.users.update({ _id: user },
  {
     $set: { "profile.address.city": "Orlando" }
  }
);