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- Cancer Therapy Supplement Natural Powder Axitinib Treatment Of Advanced Kidney Cancer CAS 319460-85-0
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- Description
- Axitinib is a selective and oral inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases 1, 2 and 3 with .
- Axitinib inhibited the phosphorylation of VEGFR-1, 2 and 3 with IC50 values of 1.2 nM, 0.2 nM and 0.1 to 0.3 nM in cells, respectively. In HUVEC cells, Axitinib inhibited VEGFR-2 stimulated cell survival with about 1000-fold selectivity against FGFR-1. Axitinib also significantly suppressed the phosphorylation of VEGF downstream signaling molecules including Akt, eNOS and ERK1/2. Besides that, axitinib inhibited VEGFR-2 phosphorylation with EC50 value of 0.49 nM in vivo. It delayed tumore growth of human xenograft tumors in mice such as M24met, HCT-116 and SN12C .
- General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
- Chemical Name:Axitinib
- Molecular Formula:C22H18N4OS
- Formula Weight:386.47
- CAS No.:319460-85-0
- Assay:99%
- Appearance:Off-White Solid powder
- Storage:Shading, confined preservation
- Usage:Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
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