[SIZE="6"]Karma[/SIZE]
[SIZE="3"]HC Ed the Undying[/SIZE]
Easiest path for karma if you have low perms is probably HC Ed the Undying. You can use cc_ascend, made by the lovely shiny robot Cheesecookie to do that! The script says it requires a lot of shinies, but it really doesn't, as my no-shiny multi can attest to. It starts at 5-day HC runs and can potentially go down to 3-day HC runs?

http://alliancefromhell.com/viewtopic.php?t=6363

[SIZE="3"]HC Community Service[/SIZE]
If you have some perms/shinies, you might be better off running it in HC Community Service, since that can get down to 2 days fairly quickly as well.

I think some good combat perms for CS so you don't get Beaten Up are Cannelloni Cocoon (hp recovery)/Saucestorm (combat spell)/Soul Saucery/Inner Sauce(mp regen)/Cannelloni Cannon (combat spell). cc_ascend also works fine for CS, although it can abort if you don't have enough adventures or get Beaten Up.

[SIZE="6"]Meat[/SIZE]
[SIZE="3"]Hidden Bowling Alley[/SIZE]

Credit goes to http://forums.kingdomofloathing.com/vb/showthread.php?t=203245 for outlining the strategy originally.

[SIZE="3"]Volcano Farming[/SIZE]
Probably the most well known and a historically popular farming method for those without lots of perms or shinies.

You'll want to buy:
-high-temperature mining mask (hot res)
-lava-proof pants (hot res)
-heat-resistant gloves (hot res)
-heat-resistant necktie (hot res)
-Misty Cloak (hp regen, can also use other sources)
-broken high-temperature mining drill
-heat-resistant sheet metal

You'll need to use the broken high-temperature mining drill with the heat-resistant sheet metal in your inventory in order to fix it. This may take several tries, in which the drill, metal, or both drill and metal may be destroyed.

Most importantly, you'll need to buy a one-day ticket to That 70s Volcano in order to access the 70s volcano for the day. At the writing of this post,

This may seem fairly expensive,

You'll want to use http://www.lethe.xyz/kol/diets.php with a value of 1 adventure = 3.3k meat (slightly more or less depending on RNG) in order to fuel your

[SIZE="3"]Tatterfarming[/SIZE]