Paranoid with Security - try this

Running main account as User NOT Administrator - having to enter a password a few times when doing specific things is worth the extra protection layer
UAC - Set to highest level
Comodo DNS - using DNSJumper I can easily switch to openDNS - GoogleDNS or whatever I choose
MSE - running
WinPatrol - running
Peerblock - running - preventative for torrents
Sandboxie - running
Spywareblaster - preventative
Clamwin - spotchecking
Emisoft Hijack Free - spotchecking

I have found a Layered defense from multiple companies has proved more effective as not one single company can catch everything... and yes  my pc runs fine with all that lot installed  lol

PrivateFirewall - running