S-23 - SARMs Powder

SARMs Powder S-23 / S23 For Boosting Exercise Endurance CAS: 1010396-29-8

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Product Name: S-23
Synonyms: S-23;(S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide;(2S)-3-(4-Chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;S 23 (contraceptive)
CAS: 1010396-29-8
MF: C18H13ClF4N2O3

S-23 Description:
S23 or (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide is a new SARM from GTX, Inc. which is developed as a possible male hormonal contraceptive. It links to the androgen receptor (AR) more intensely (with a Ki of 1.7nM) as compared to older medicines such as Andarine.


In animal research, S23 displayed a good ratio of anabolic to androgenic effects as well as dose-dependent restraint of spermatogenesis (the course of sperm cell development) with unprompted recuperation after end of treatment.


S-23 is an investigational SARM, as a potential male hormonal contraceptive. It binds to the receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.

How safe is S23 ?

Many people want to know S-23's safety before any action is made. Most of these SARMs have not yet been tested on humans, but only on rats or mice. This is also true for S23.

SARM 23 can be found in some webstores that sell research chemicals online. Not much is known about the working or side effects of SARMs in humans, so caution is advised. And a 2009 animal study, in which researchers at GTx tried S23 out on rats, suggests that S23 is a little more risky than other SARMS.

Function


S-23 not only boosted muscle mass, but also reduced fat mass, as studied. SARMs have a bit of a 'soft' image in the doping world. They don't stimulate muscle growth in the way that anabolic steroids do, but many users say that they are safer.



There are no studies yet that confirm this suspicion. But that S23 is not one of the safer SARMs - we'd be willing to wager a bottle of BCAAs on that. S23 halts the production of sperm in the testes. In fact it does this so well that the researchers suspect S23 might be a good candidate for a male contraceptive. If this is the case it would probably have to be part of a cocktail that also contains an estradiol analogue, the researchers discovered. The lab animals lost their libido when they were given S23 on its own, and only recovered this when they were given estradiol benzoate together with the S23.

Bodybuilding Uses


S-23 is an orally active nonsteroidal SARM with a very high binding affinity to androgen receptors. This makes it stronger than other popular SARMS like Ostabolic (mk-2866) or Andarine (S-4). Therefore, the main effects of S-23 are increased muscle mass, decreased fat mass, and a decrease in the size of the prostate.

Additionally, in a study done on rats a dose equivalent to 15 milligrams (mg) for a 180lb male was shown to also increase bone mineral density, as well as promote muscle mass growth and fat loss. Hence, S-23 is versatile in that it can be used for bulking and for cutting.

Side Effects


The main side effect of S-23 use is the suppression of natural testosterone production. This is what gives it potential as a male contraceptive, and also makes it very different from other SARMS. While ostarine (ostabolic), andarine (s4), and Anabolicum (LGD) may cause a mild shut down, S-23 is extremely suppressive. Consequently, this will be a major factor in deciding whether to use this SARM or opt for the more widespread choices.

Dosages and Cycles


Dosages of S-23 can vary, and they will be very dependent on what the goal is. For instance, if a user were looking for muscle building and fat loss, a dose of 15-25 mgs per day would be appropriate. On the other hand, if someone was looking to use it for the contraceptive effects, a higher dose of around 50 mgs per day would be more effective.

Conclusion

S-23 has many potential benefits that range from muscle building and fat loss, to being a possible male contraceptive. Even though this SARM may seem very intriguing, it is still in a very early stage of development and study. Thus, I would proceed with caution when considering this compound. Keep in mind that there are other SARMS on the market today, such as ostabolic and testolone, which give similar muscle building and fat loss effects and are much more studied. Besides, other SARMS will also cause much less suppression of natural testosterone production, allowing the user to run a considerably milder and shorter PCT. All in all, I would recommend sticking to the tried and true until more research is done on S-23.