Ascension Guide

13th - 240,353,606 - Total HC: 350,188,126 - 42.945 undecillion
Chimera (40,353,607)
Eye of the Wrinkler (99,999,999) *no true effect on gameplay, but can be useful
Stevia Caelestis (100M)

14th - 500M - Total HC: 850,188,126 - 614.54 undecillion
Sugar Baking (200M)
Diabetica Daemonicus (300M)

15th - 1B - Total HC: 1,850,188,126 - 6.3336 duodecillion
Sugar Craving (400M)
Sugar Aging Process (600M)

16th - 2B - Total HC: 3,850,188,126 - 57.075 duodecillion
Sucralosia Inutilis (1B)
Sugar Crystal Cookie (1B)

17th - 2,111,111,110 - Total HC: 5,961,299,236 - 211.85 duodecillion
Shimmering Veil (999,999,999)
Keepsakes (1,111,111,111)

18th - 14,999,999,985 - Total HC: 20,961,299,221 - 9.2099 tredecillion
Cosmic Beginner's Luck (14,999,999,985)

19th - 14,999,999,985 - Total HC: 35,961,299,206 - 46.506 tredecillion
Reinforced Membrane (14,999,999,985)

20th - 77,777,777,777 - Total HC: 113,739,076,983 - 1.4714 quattuordecillion
Fortune Cookies (77,777,777,777)

21st - 333B - Total HC: 446,739,076,983 - 89.159 quattuordecillion
Box of Pastries (333B)

22nd - 333B - Total HC: 779,739,076,983 - 474.08 quattuordecillion
Not Cookies (333B)

23rd - 333B - Total HC: 1,112,739,076,983 - 1.3778 quindecillion
Maybe Cookies (333B)

Permaslots
==========
(440 - 21B HC [when you unlock Cosmic Beginner's Luck]) - slot these upgrades in as you unlock the slots
Permaslot 1 - highest illion fingers upgrade
Permaslot 2 - highest kitten
Permaslot 3 - highest Javascript Console upgrade
Permaslot 4 - 2nd highest kitten
Permaslot 5 - omelette

(21B - 114B [when you purchase Fortune Cookies])
Permaslot 1 - highest illion fingers upgrade (using CBL) OR second highest building biscuit OR a GC frequency upgrade
Permaslot 2 - highest building biscuit
Permaslot 3 - highest kitten
Permaslot 4 - highest Javascript Console upgrade
Permaslot 5 - 2nd highest kitten

(114B and beyond)
Permaslot 1 - highest illion fingers upgrade (CBL) OR second highest building biscuit OR a GC frequency upgrade
Permaslot 2 - highest kitten
Permaslot 3 - highest Javascript Console upgrade OR fortune console upgrade
Permaslot 4 - Fortune#103 [Kitten]
Permaslot 5 - highest building biscuit

Past 1.12T HC, your permaslots will really depend based on your needs, such as if you want to use CBL, don't want to wait to buy expensive upgrades, or want to get some useful holiday upgrades out of the way first, like omelette.